Author of

• 25925

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  P1.05 - Interventional Diagnostics/Pulmonology (Not CME Accredited Session) (ID 937)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall

  • 26501

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    P1.05-24 - Clinical Characteristics and Prognostic Analysis of Multiple Primary Malignant<br /> Neoplasms in Patients with Lung Cancer (ID 12840)

    16:45 - 18:00  |  Author(s): Jingjing Hou
    • Abstract
    • Slides

    Background
    

    To investigate the clinical characteristics, survival status and prognostic factors of multiple primary malignant neoplasm (MPMN) patients with lung cancer.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    The clinical and pathological data of 14,528 lung cancer patients who were diagnosed and treated in the affiliated cancer hospital of Zhengzhou University from January 2008 to August 2015 were retrospectively analyzed.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Of the total lung cancer patients, 2.5% (364/14,528) were MPMN cases and 3.6% (13/364) were diagnosed with 3 primary malignancies, 0.3% (1/364) with 4 primary malignancies and 96.2% (350/364) with 2 primary malignancies. Among the
    350 lung cancer patients diagnosed with 2 primary malignancies, 26.6% (93/350) had lung cancer diagnosed first (LCF) and 73.4% (257/350) had other cancers diagnosed initially (OCF), whereas synchronous MPMN (SMPMN) accounted for 21.1% (74/350) and metachronous MPMN (MMPMN) accounted for 78.9% (276/350) of cases.Detection of first primary neoplasms were at an early stage for LCF patients and the age of the first lung cancer diagnosis was 59.3 years vs 55.4 years in the OCF group (P = 0.008), whereas the onset age of second primary neoplasm diagnosis was similar in both groups (62.5 and 61.6 years, P = 0.544). The median survival times of the OCF and LCF groups were 86 months vs 58 months (P < 0.001). The median survival times of MMPMN and SMPMN patients were 94 months vs 27 months (P < 0.001).Multivariate analysis showed that SMPMN, LCF and the age of the primary cancer diagnosed first (≥ 60 years) were independent factors for inferior prognosis of patients.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Though LCF was diagnosed in earlier stages than OCF, the survival rate was inferior and the time until the development of the second primary malignancy was shorter than in the OCF group. SMPMN patients had a worse prognosis than MMPMN
    patients in both the LCF and OCF groups. Also ≥ 60 years of age at the time of the primary cancer diagnosis was an independent factor for inferior prognosis in all patients.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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