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Midori Tanaka



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    P1.05 - Interventional Diagnostics/Pulmonology (Not CME Accredited Session) (ID 937)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.05-20 - Therapeutic Condition of Photodynamic Therapy Using Taraporfin Sodium for Central Airway Stenosis (ID 13807)

      16:45 - 18:00  |  Author(s): Midori Tanaka

      • Abstract
      • Slides

      Background

      Central airway stenosis is life threatening, and some kinds of debulking procedures are recommended especially for endobronchial lesions. Previous reports have shown the efficacy and safety of PDT using porphimer sodium as a photosensitizer in debulking. However, the detail of taraporfin sodium, the second generation photosensitizer in this setting has not been known well yet. Therefore, we reviewed the cases that underwent PDT using taraporfin sodium for central airway stenosis.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Consecutive patients who underwent PDT using taraporfin sodium for central airway stenosis in our institute from 2012 to 2017 were collected. The dose of the photosensitizer, the time to laser irradiation, the laser dose, the therapeutic effect and the adverse events were assessed.

      4c3880bb027f159e801041b1021e88e8 Result

      Seventeen lesions were performed PDT in 9 patients (the average number of lesions was 1.9 per parson). The dose of taraporfin sodium was 40 mg/m2, and the time from administration of the photosensitizer to laser irradiation was 5 hours in all cases. The laser dose was 150 J/cm2 in 5 lesions, while 100 J/cm2 in 11 lesions, and 50 J/cm2 in 1 lesion. This treatment condition was selected in accordance with PDT for central type early stage lung cancer: the dose of the photosensitizer was 40 mg/m2, the time to laser irradiation was 4-6 hours, and the laser dose was 100 J/cm2. Meanwhile, 2 patients were treated after electrocautery, and 1 patient was after argon plasma coagulation. Almost all patients showed improvement of airway stenosis except for 1 lesion with the laser dose of 50 J/cm2. There was no significant difference in the effect between the laser dose of 150 J/cm2 and 100 J/cm2. There was no serious adverse event.

      8eea62084ca7e541d918e823422bd82e Conclusion

      PDT using taraporfin sodium is a feasible procedure with sufficient efficacy and safety for central airway stenosis..

      6f8b794f3246b0c1e1780bb4d4d5dc53

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