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  P2.03 - Biology (Not CME Accredited Session) (ID 952)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 26968

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    P2.03-30 - Proteins Involved in Necroptosis and DNA Damage Repair and Survival of Stage I Non-Small-Cell Lung Cancer Patients (ID 13031)

    16:45 - 18:00  |  Author(s): Min-Seong Jo
    • Abstract
    • Slides

    Background
    

    Survival of patients with stage I non-small-cell lung cancer (NSCLC) was indicative of significant variability with biological complexity. In addition to repairing DNA damage, understanding for necroptosis as new mechanism of cell death is rapidly growing as one of the hallmark of cancer. Therefore, the development of a prognostic biomarker focusing on necroptosis and DNA damage is an intriguing issue.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    Expression of eight proteins (RIPK3, MLKL, PELI1, P53, ATM, gH2AX, Chk2, and BRCA1) and overall survival were investigated in 394 pathological stage I NSCLC patients.

    4c3880bb027f159e801041b1021e88e8 Result
    

    The proteins involved in necroptosis or DNA damage repair exhibited differential expression between squamous cell carcinoma and other histology. Low expression of RIPK3 showed a trend for having worse survival in the entire cohort. Analysis performed based on histology revealed that expression of RIPK3, PELI1, P53, or BRCA1 was an independent prognostic factor in squamous cell carcinoma patients (aHR, Cox P: 2.292, 0.008 for RIPK3; 2.007, 0.033 for PELI1; 0.391, 0.003 for P53; 2.088, 0.018 for BRCA1). When combined effect of RIPK3 or PELI1 with P53 or DNA damage repair proteins analyzed, the effect on survival is was markedly strengthened in squamous cell carcinoma patients. However, these effects were not detected in adenocarcinoma patients.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Expression or their combination of proteins involved in necroptosis and DNA damage repair is an important determinant of survival in stage I squamous cell carcinoma patients.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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