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    P1.03 - Biology (Not CME Accredited Session) (ID 935)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.03-14 - Interaction Between Celecoxib and Cisplatin is Dependent on The p53 Status in Human NSCLC Cell Lines (ID 11232)

      16:45 - 18:00  |  Author(s): Li Ma

      • Abstract
      • Slides

      Background

      As a cyclooxygenase-2 inhibitor, the potential of celecoxib, to enhance the efficacy of chemotherapy is being investigated in clinical trials related to cancer treatment.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      In this study, we investigated whether celecoxib would increase the anti-proliferative effects of cisplatin in human lung cancer cell lines.

      4c3880bb027f159e801041b1021e88e8 Result

      The results demonstrated the synergistic effects of celecoxib with cisplatin in wild-type p53 cells and their antagonistic effects in mutated or deleted p53 cells. Combination indices of 0.82–0.93 reflected a synergistic effect between celecoxib and cisplatin in lung cancer cells with wild-type p53. Combination indices of 1.63–3.00 reflected antagonism between celecoxib and cisplatin in lung cancer cells with mutated or deleted p53. Apoptosis was shown to increase with the addition of celecoxib and cisplatin. Apoptosis was accomplished by the downregulation of slug expression. Celecoxib increased the nuclear localization of active p53 in lung cancer cells of wild-type p53.

      8eea62084ca7e541d918e823422bd82e Conclusion

      Taken together, our data demonstrated clear synergistic effects in wild-type p53 cells and antagonistic effects in mutated or deleted p53 cells when celecoxib and cisplatin are combined.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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