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Ziying Gong



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    P1.03 - Biology (Not CME Accredited Session) (ID 935)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.03-09 - ROS1 Rearrangement in Pulmonary Sarcomatoid Carcinoma: A Retrospective Study of the Real World (ID 11206)

      16:45 - 18:00  |  Author(s): Ziying Gong

      • Abstract
      • Slides

      Background

      Pulmonary sarcomatoid carcinoma (PSC) is a recognized category of highly aggressive and poorly differentiated non-small-cell lung carcinoma (NSCLC), with five different subtypes: pleomorphic, spindle, giant cell, carcinosarcoma, and pulmonary blastoma. Although uncommon (0.1% to 0.4% of all pulmonary malignancies), their clinical importance is underscored by poorer prognosis and higher rate of resistance to conventional chemotherapy than other NSCLCs. And the incidence of c-ros oncogene 1, receptor tyrosine kinase (ROS1) rearrangement in PSC is controversial. The aim of this study was to reveal the reliable frequency and the clinical-pathologic characteristics of PSC with ROS1 rearrangement in Chinese population.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      A total of 35 patients with PSC were recruited between September 2007 and December 2017. The status of ROS1 rearrangement was detected by reverse transcription polymerase chain reaction (RT-PCR).

      4c3880bb027f159e801041b1021e88e8 Result

      Of this study, three patients were identified with ROS1 rearrangement in Chinese PSC population (2.86%, 1/35). The patient was a pulmonary pleomorphic carcinoma (PPC).

      8eea62084ca7e541d918e823422bd82e Conclusion

      The incidence rates of ROS1 rearrangement in PSC in the Chinese population are more than those of other subtypes of NSCLC. Crizotinib may serve as an effective treatment for ROS1-rearranged PSC.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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