Author of

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  P1.03 - Biology (Not CME Accredited Session) (ID 935)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall

  • 26403

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    P1.03-08 - Detection of PTCH1 Gene Variants in Non-Small Cell Lung Cancer Patients from China (ID 11116)

    16:45 - 18:00  |  Author(s): Tianwen Xu
    • Abstract
    • Slides

    Background
    

    Recently, the Patched homolog 1 gene (PTCH1) gene mutations are identified in non-small-cell lung cancer (NSCLC). While the genetic spectrum of PTCH1 mutation NSCLC patients is unclear. The aim of this study is to investigate mutations and prognosis of NSCLC harboring PTCH1 mutations.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    A total of 269 patients with non-small-cell lung cancer were recruited between July 2012 and December 2015. The status of PTCH1 mutation and other genes were detected by next generation sequencing.

    4c3880bb027f159e801041b1021e88e8 Result
    

    PTCH1 gene mutation rate was 6.32% (17/269) in non-small cell lung cancer, including S827G (2 patients), G445S (1 patient), A1130T (1 patient), L1036F (1 patient), E173D (1 patient), P1210L (1 patient), Y820* (1 patient), D710E (1 patient), C37W (1 patient), N258I (1 patient), F614Y (1 patient), P681S (1 patient), V1381G (1 patient), G37R (1 patient), A741V (1 patient) and P1282L plus R893H (1 patient), and median overall survival (OS) for these patients was 18.0 months. Among them, all patients were PTCH1 gene with co-occurring mutation. Briefly, patients with (n=5) or without (n=12) co-occurring EGFR mutations had a median OS of 22.0 months and 18.0 months respectively (P=0.25); patients with (n=11) or without (n=6) co-occurring TP53 mutations had a median OS of 18.0 months and 14.0 months respectively (P=0.28); patients with (n=2) or without (n=15) co-occurring BRAF mutations had a median OS of 4.0 months and 18.0 months respectively (P=0.14); patients with (n=2) or without (n=8) co-occurring PIK3CA mutations had a median OS of 17.0 months and 18.0 months respectively (P=0.96).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    PTCH1 gene mutation coexists with other gene mutation in NSCLC. EGFR, TP53, BRAF and PIK3CA gene accompanied may have less correlation with PTCH1 mutation in NSCLC patients. Analysis of PTCH1 mutations shows promise as a way to refine individual patients with NSCLC, and provides more insight into effective treatment strategies for patients with PTCH1 mutations.

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