Author of

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  P1.03 - Biology (Not CME Accredited Session) (ID 935)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall

  • 26396

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    P1.03-01 - Association of APC Mutations with Chinese Patients Molecular Spectrum in Non-Small-Cell Lung Cancer (ID 11109)

    16:45 - 18:00  |  Presenting Author(s): Shuitu Feng
    • Abstract
    • Slides

    Background
    

    The role of adenomatous polyposis coli (APC) gene in mitosis might be critical for regulation of genomic stability and chromosome segregation. APC gene mutations have been associated to have a role in colon cancer and since gastric and colon tumors share some common genetic lesions, it is relevant to investigate the role of APC tumor suppressor gene in gastric cancer. While the genetic sites of APC mutation NSCLC patients is unclear. The aim of this study is to investigate mutations and prognosis of NSCLC harboring APC mutations.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    A total of 294 patients with non-small-cell lung cancer were recruited between July 2012 and December 2015. The status of APC mutation and other genes were detected by next generation sequencing.

    4c3880bb027f159e801041b1021e88e8 Result
    

    APC gene mutation rate was 4.08% (12/294) in non-small cell lung cancer, including R232* (1 patient), Y159* (1 patient), R564* (1 patient), E984Dfs*21 (1 patient), K534Nfs*15 (1 patient), Q161* (1 patient), K1437* (1 patient), K792* (1 patient), T1556Nfs*3 (1 patient), N32S (1 patient), R259W (1 patient) and N372D (1 patient) , and median overall survival (OS) for these patients was 9.0 months. Among them, all patients were APC gene with co-occurring mutation. Briefly, patients with (n=8) or without (n=4) co-occurring EGFR mutations had a median OS of 9.0 months and 6.0 months respectively (P=0.01); patients with (n=6) or without (n=6) co-occurring TP53 mutations had a median OS of 6.5 months and 11.0 months respectively (P=0.04); patients with (n=4) or without (n=8) co-occurring KRAS mutations had a median OS of 16.5 months and 9.0 months respectively (P=0.27); patients with (n=2) or without (n=10) co-occurring CDKN2A mutations had a median OS of 6.5 months and 11.5 months respectively (P=0.68).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    The present study expanded the database on APC gene mutations in NSCLC and enriched the spectrum of known somatic mutations of the APC gene. Chemotherapy may be considered as a possible treatment for carriers of the mutation. EGFR mutated accompanied mutations might play a good prognosis in APC gene mutation NSCLC.

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