Virtual Library

Start Your Search

Buhai Wang



Author of

  • +

    P1.01 - Advanced NSCLC (Not CME Accredited Session) (ID 933)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
    • +

      P1.01-112 - Osimertinib vs Standard of Care (SoC) EGFR-TKI as First-Line Treatment in Chinese Patients With EGFRm Advanced NSCLC (ID 12211)

      16:45 - 18:00  |  Author(s): Buhai Wang

      • Abstract
      • Slides

      Background

      Osimertinib is an irreversible, central nervous system (CNS) active EGFR-TKI, selective for both EGFRm and T790M resistance mutations. FLAURA (NCT02296125) is a PhIII, double-blind, randomized study assessing efficacy and safety of osimertinib vs SoC EGFR-TKI (erlotinib/gefitinib) in first-line patients with EGFRm advanced NSCLC. FLAURA results (556 patients, globally) are published. We present the China cohort results.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      The cohort included self-identified Chinese patients, enrolled in China. Eligible patients: ≥18 years, Ex19del/L858R EGFRm advanced NSCLC, no prior EGFR-TKI/systemic anti-cancer therapy for advanced disease. Neurologically stable patients with CNS metastases were allowed, if definitive treatment/corticosteroids were completed ≥2 weeks before enrolment. Patients were randomized 1:1 to osimertinib 80 mg once daily (qd) orally or SoC EGFR-TKI (gefitinib 250 mg qd orally selected by all Chinese sites), stratified by mutation status (Ex19del/L858R). Primary endpoint: progression-free survival (PFS) by RECIST v1.1, per investigator. Data cutoff: 10/01/2018.

      4c3880bb027f159e801041b1021e88e8 Result

      Overall, 136 patients were randomized (osimertinib n=71; SoC n=65); 19 were also included in the global analysis. Baseline characteristics were balanced across arms (osimertinib/SoC): female 61/71%; smoking history 25/23%; WHO performance status 1 90/80%; Ex19del 51/51%, L858R 49/49%; CNS metastases 24/32%.

      Efficacy endpoint Osimertinib
      n=71
      SoC
      n=65

      PFS events, total patients
      (% maturity)

      40
      (56%)
      51
      (78%)
      PFS hazard ratio (HR)*
      (95% CI)
      0.56 (0.37, 0.85); p=0.007
      Median PFS, months
      (95% CI)
      17.8
      (13.6, 20.7)
      9.8
      (8.3, 13.8)
      Objective response rate (ORR),
      % (95% CI)
      83%
      (72, 91)
      75%
      (63, 85)

      Median duration of response (DoR), months
      (95% CI)

      16.4
      (12.3, NC)
      10.9
      (8.3, 13.8)
      *A hazard ratio <1 favours osimertinib.

      PFS benefit was observed across all subgroups, irrespective of EGFR mutation status and including patients with/without CNS metastases at study entry. Median total treatment duration: osimertinib, 18.9 months; SoC, 13.6 months. No new safety signals were reported. Numerical increase in grade ≥3 AEs was reported in the osimertinib arm (49%) versus SoC arm (23%). Most grade ≥3 AEs in the osimertinib arm were investigator-reported laboratory and disease-related AEs; incidence of non-laboratory-related events was low. AEs leading to discontinuation: osimertinib, 13%; SoC, 6%. In the osimertinib arm, most AEs leading to discontinuation were fatal disease-related events.

      8eea62084ca7e541d918e823422bd82e Conclusion

      Osimertinib improved PFS vs SoC EGFR-TKI (HR: 0.56) as first-line treatment in Chinese patients with EGFRm advanced NSCLC, consistent with the global analysis.

      6f8b794f3246b0c1e1780bb4d4d5dc53

      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.

  • +

    P2.15 - Treatment in the Real World - Support, Survivorship, Systems Research (Not CME Accredited Session) (ID 964)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
    • +

      P2.15-30 - Marital Status and Survival in Patients with Lung Cancer (ID 12701)

      16:45 - 18:00  |  Presenting Author(s): Buhai Wang

      • Abstract
      • Slides

      Background

      Multiple studies have shown that marital status is associated with the survival of various types of cancer patients. Majority of the findings support high survival rate for married patients is closely related to well social support and family care. However, another conclusion that there is no correlation between marital status and the length of cancer survival makes it controversial when talking about the survival benefit of cancer patients. To better explain the issue, here we did further investigation to study the effect of marital status on survival of lung cancer patients.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      In this study, we retrospectively extracted 136535 eligible lung cancer patients from the Surveillance, Epidemiology, and End Results (SEER) database in the period from 2010 to 2014. Marital status was categorized as married, divorced/separated, widowed, and Single/Partner. The latter three are classified as unmarried. Meanwhile, 1:1 propensity scores for marital status, which were calculated for each patient using a multivariable logistic regression model, were used to match 64749 unmarried patients with 71786 married patients. With accurate matching, the fault tolerance rate is set to 0. Chi-square tests were used to investigate the association between marital status and other variables. The Kaplan-Meier test was adopted to compare survival curves of different groups. Multivariate Cox regression analyses were conducted to estimate the effect of marital status on OS and CSS.

      4c3880bb027f159e801041b1021e88e8 Result

      We exactly matched 37105 unmarried patients with 37105 married patients. Married patients had higher OS than unmarried patients before matching (OS: HR: 0.903(0.891-0.916), P<0.001; CSS: HR: 0.917(0.904-0.931), P<0.001). But after matching, the OS is undifferentiated between married patients and unmarried patients (OS: HR: 0.985(0.967-1.003), P=0.1; CSS: HR: 1.004(0.985-1.024), P =0.695). Then we carried out subgroup COX analyses stratified by AJCC stage for OS and CSS. Result hints that the prognosis of married patients is better than that of unmarried patients in Stage III and IV, there is no significant difference between the stage I and II patients in lung cancer.

      8eea62084ca7e541d918e823422bd82e Conclusion

      Marital status affects the prognosis of patients with advanced lung cancer. the prognosis of married patients is better than that of unmarried patients.

      6f8b794f3246b0c1e1780bb4d4d5dc53

      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.