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Fatma Basal



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    P1.01 - Advanced NSCLC (Not CME Accredited Session) (ID 933)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.01-45 - Crizotinib Efficacy in ALK-Positive Advanced Stage Non-Small Cell Lung Cancer Patients: A Real-World Experience from Turkey (ID 14012)

      16:45 - 18:00  |  Author(s): Fatma Basal

      • Abstract

      Background

      ALK mutation is observed in 4% of patients diagnosed with NSCLC. The present study aimed to evaluate the efficacy of crizotinib, an ALK inhibitor, and clinical characteristics of ALK-positive NSCLC patients.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      In this multicenter, retrospective study, data of ALK-positive advanced stage NSCLC patients who received crizotinib were retrieved from hospital records.

      4c3880bb027f159e801041b1021e88e8 Result

      Data of 353 ALK-positive metastatic NSCLC patients receiving crizotinib in any treatment line were analyzed. The mean age of the patients was 53.2±12.6 years [median, 53 years (21-85 years)] and 193 (54.7%) patients were male. Age at diagnosis was significantly higher in males than in females (54.8±11.8 years and 51.3±13.2 years, respectively; p=0.044). The rate of patients who never smoked was 50.1%. The most common histological subtype was adenocarcinoma (96%). The frequency of brain metastasis at the time of diagnosis was 23.4%. The most common initial symptoms were cough (56%) and dyspnea (53%). Initial ECOG score was 0 or 1 in 80% of the patients. Crizotinib had been used in 37% of the patients in the 1st-line treatment, in 45% of the patients in the 2nd-line treatment, and in 18% of the patients in the ≥3rd-line treatment.

      Table 1. Response rates of the patients

      Treatment line

      Overall
      N (%)

      1
      N (%)

      2
      N (%)

      3
      N (%)

      Other
      N (%)

      Complete response

      28 (7.9)

      9 (7.3)

      14 (8.9)

      4 (9.8)

      1 (5.6)

      Partial response

      217 (61.5)

      78 (62.9)

      103 (65.2)

      25 (61.0)

      10 (55.6)

      Stable disease

      50 (14.2)

      18 (14.5)

      21 (13.3)

      7 (17.1)

      4 (22.2)

      Progressive disease

      67 (13.3)

      19 (15.3)

      20 (12.7)

      5 (12.2)

      3 (16.7)

      Undefined

      11 (3.1)

      ORR

      245 (69.4)

      87 (70.2)

      117 (74.1)

      29 (70.8)

      11 (61.2)

      DCR

      295 (83.6)

      105 (84.7)

      138 (87.4)

      36 (87.1)

      7 (83.4)

      Undefined

      11 (3.1)

      ORR was 69.4% and DCR was 83.6% (Table 1). ORR and DCR in the patients received crizotinib were 70.2% and 84.7% in the 1st-line treatment, respectively and were 74.1% and 87.4% in the 2nd-line treatment, respectively. The frequency of brain metastasis was 40.2% at 12 months. Of these patients, the median PFS and OS were 11.3 and 28.0 months, respectively.

      The most common side effects were fatigue, visual disturbances, nausea, abdominal discomfort, and pretibial edema.

      8eea62084ca7e541d918e823422bd82e Conclusion

      Clinical characteristics of ALK-positive patients and crizotinib efficacy are consistent with studies. Response rates and survival outcomes are similar regardless of treatment lines. Crizotinib is safely used in these patients.

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    P2.17 - Treatment of Locoregional Disease - NSCLC (Not CME Accredited Session) (ID 966)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
    • +

      P2.17-05 - Consolidation Chemotherapy in Patients with Locally Advanced Non-Small Cell Lung Cancer After Concurrent Chemoradiotherapy (ID 14093)

      16:45 - 18:00  |  Presenting Author(s): Fatma Basal

      • Abstract
      • Slides

      Background

      The effect of consolidation chemotherapy after concurrent chemoradiotherapy (CRT) is controversial in patients with locally advanced non-small cell lung cancer (NSCLC). In this study we aimed to compare the impact of consolidation chemotherapy after concurrent CRT and concurrent CRT alone on survival outcome and safety in patients with locally advanced NSCLC.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      We retrospectively analyzed 136 patients with unresected locally advanced NSCLC that received consolidation chemotherapy after concurrent CRT and concurrent CRT alone between October 2009 and March 2018, in a single center. The groups were compared regarding overall survival (os), progression-free survival (pfs) and toxicities.

      4c3880bb027f159e801041b1021e88e8 Result

      In our study, 120 patients were (88.2%) male and the median age was 63 (42-82). The most seen histologic types of tumor was squamous cell cancer (SCC- 63.2%). Among 136 patients; 77 patients (56.6%) received consolidation chemotherapy after concurrent CRT, 59 (43.4%) patients received concurrent CRT alone. The median PFS was 12.8 months and the median OS was 25.2 months for all patients. The median PFS was 12.8 months and 12.3 months for consolidation group and concurrent CRT group, respectively (p=0.80). The median OS was 23.6 months and 27 months for consolidation group and concurrent CRT group, respectively (p=0.84). There was no significant difference between two groups regarding PFS or OS.

      Considering all the patients, there was no grade 3-4 toxicities excluding cytopenia. We reported the toxicities that nausea (77.2%), vomiting (76.5%), fatique (81.6%), mucositis ( 28.7%), stomatitis (18.1%), neuropathy (27.2%), neutropenia (39.7%), trombocytopenia (% 9.6), anemia (24.3%), febrile neutropenia (5.9%), When we compare two groups regarding treatment-related toxicities, there was no significant difference between two goups.

      8eea62084ca7e541d918e823422bd82e Conclusion

      In the present study, our results revealed that the patients treated with consolidation chemotherapy after concurrent CRT had no better outcomes than treated with concurrent CRT alone.

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