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Katherine Hoversten
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P1.01 - Advanced NSCLC (Not CME Accredited Session) (ID 933)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 1
- Moderators:
- Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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P1.01-17 - Immune-Related Adverse Events in Patients with Metastatic Non-Small Cell Lung Cancer: Sex Differences and Response to Therapy. (ID 12642)
16:45 - 18:00 | Author(s): Katherine Hoversten
- Abstract
Background
Sex differences in non-small cell lung cancer (NSCLC) outcomes have been described. Immune-related adverse events (IRAEs) have emerged as a serious clinical problem in the use of immune checkpoint inhibitors (ICI). Risk factors for IRAEs and their association with response to therapy remain controversial. Therefore, we studied sex differences in IRAEs and their association with response to therapy.
a9ded1e5ce5d75814730bb4caaf49419 Method
All patients with metastatic NSCLC treated with anti-PD1 and anti-PDL1 therapy at Mayo Clinic Rochester and Florida from 2015 to 2018 were reviewed. Patients receiving treatment at an outside facility or with history autoimmune disorders were excluded. Kaplan-Meier method was used for time-to-event analysis.
4c3880bb027f159e801041b1021e88e8 Result
231 patients were identified, 120 (52%) were women and 111 (48%) were men. Baseline characteristics and ICI distribution were similar among groups (Table 1). Women were more likely to experience IRAEs compared to men (48% vs. 31%, p<0.008). Among patients with IRAEs, women were more likely to be prescribed systemic steroids (63% vs. 41%, p<0.02). Women were more likely to develop pneumonitis (23% vs. 12%, p<0.03) and arthralgia (17% vs. 3%, p<0.04). However, dermatologic toxicities (35% vs. 9%, p<0.002) were more commonly seen in men. In 17% of women the ICI was discontinued due to toxicity (men 7%). Besides sex, no other clinical characteristic was associated with increased IRAEs. Women with IRAEs were more likely to have a radiographic response compared with women without IRAEs (78% vs. 23%, p<0.0001), although this was not observed in men (37% vs. 26%, p>0.22). Better PFS was observed in women with IRAEs (10 months vs. 3.3 months, p<0.0006) compared to women without IRAEs.
Women % (n)
Men % (n)
p value
PD-L1 expression ≥1%
30 (36)
34 (38)
0.29
Adenocarcinoma
77 (92)
66 (73)
0.02
Bone metastasis
34 (41)
47 (52)
0.05
Brain metastasis
20 (24)
22 (24)
0.76
Liver metastasis
13 (15)
10 (11)
0.53
Prior chemotherapy
74 (89)
85 (94)
0.06
Prior palliative radiation
53 (63)
57 (63)
0.52
IRAEs
48 (57)
31 (34)
0.006
≥3 grade IRAEs
42 (24)
29 (10)
0.22
Received systemic steroids
63 (36)
41 (14)
0.02
Required intravenous steroids
30 (17)
24 (8)
0.47
Women with metastatic NSCLC are more likely to experience IRAEs compared to men. In women, an association between IRAEs and response to therapy was observed. Larger studies are needed to investigate the mechanisms underlying these associations.
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