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Yushi Saito



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    OA11 - Thymic and Other Thoracic Tumours: Targeted Therapies, Biomarkers and Neo/Adjuvant Radiotherapy (ID 919)

    • Event: WCLC 2018
    • Type: Oral Abstract Session
    • Track: Thymoma/Other Thoracic Malignancies
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 13:30 - 15:00, Room 205 BD
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      OA11.04 - A Comparative Study of PD-L1 Immunohistochemical Assays with Four Reliable Antibodies in Thymic Carcinoma (ID 12114)

      14:05 - 14:15  |  Author(s): Yushi Saito

      • Abstract
      • Presentation
      • Slides

      Background

      Currently, programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) targeted therapy has not been established for thymic carcinoma (TC) yet, and limited information is available regarding the expression pattern of PD-L1 in TC. Four immunohistochemical assays are registered with the US Food and Drug Administration to detect the expression of PD-L1. We investigated the PD-L1 expression in thymic carcinomas using these four diagnostic assays.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      The clinicopathological data of 53 TC patients were reviewed and their specimens were subjected to four PD-L1 assays with different antibodies (22C3, 28-8, SP142, and SP263). We examined tumor proportion scores (TPS) in each case and the cutoff values were settled at 1% for 22C3, 1% for 28-8, 1% for SP142, and 25% for SP263. Date were correlated to clinicopathologic parameters and outcomes.

      4c3880bb027f159e801041b1021e88e8 Result

      The study population included 32 male patients and 21 female patients (median age, 61 years). In the TPS, the four assays showed similar scores in each case. Pairwise analyses of the TPS for the four assays showed high concordance among the four assays (the Spearman’s rank correlation coefficients were all >0.9). Histopathologically, high TPS was observed in squamous cell carcinomas (SqCCs). Using cutoffs, 34 cases (64.2%) with 22C3, 41 cases (77.4%) with 28-8, 43 cases (81.1%) with SP142, and 26 cases (49.1%) with SP263 were detected as PD-L1 positive. In SqCCs, the high expression of PD-L1 (TPS ≥50%) were associated with early stage cancer when evaluated with 22C3 (p=0.0205), 28-8 (p=0.0448), and SP263 (p=0.0486), respectively. However the high expression of PD-L1 were not associated with sex, age, tumor size, and curability. The SqCC patients with high expression of PD-L1 tended to show longer overall survival; p=0.0250 in 22C3, p=0.0719 in 28-8, p=0.1064 in SP142, and p=0.0675 in SP263.

      8eea62084ca7e541d918e823422bd82e Conclusion

      The present study revealed that the TC patients, especially SqCC patients, showed high PD-L1 positivity and that the staining pattern showed high concordance among the four assays. High expression of PD-L1 might be a prognostic predictor, though observed effect was independent on the assay. Our results suggest that the PD-1/PD-L1 pathway is a potential immunotherapeutic target in TC.

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