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  OA09 - Prevention and Cessation (ID 909)

  • Event: WCLC 2018
  • Type: Oral Abstract Session
  • Track: Prevention and Tobacco Control
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/24/2018, 15:15 - 16:45, Room 205 BD

  • 25886

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    OA09.07 - Association Between Outdoor Air Pollution And Lung Cancer in Female Never Smokers (ID 14485)

    16:20 - 16:30  |  Author(s): Sim Ladhar
    • Abstract
    • Presentation

    Background
    

    Long term exposure to ambient particulate matter (PM_2.5) has been associated with an increased risk of developing lung cancer, and is estimated to be responsible for ~23% of global lung cancer deaths. No current lung cancer screening risk prediction model uses air pollution as an individual risk factor in its risk calculation. As smoking rates decrease globally, and air pollution increases, it is important to assess the effect of long term outdoor air pollution exposure on lung cancer risk especially in never smokers.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    We enrolled 421 patients with newly diagnosed lung cancer presenting to BC Cancer and conducted a detailed residential history from birth to estimate their air pollution exposure since 1996 when accurate high-resolution concentration estimates of PM_2.5 particulate matter derived from satellite observations and ground measurements became available. The average PM_2.5 exposure was quantified by combining residential histories with exposure data.

    4c3880bb027f159e801041b1021e88e8 Result
    

    The demographics of the 262(62%) ever smokers, and 159(38%) never smokers with lung cancer are shown in Table 1. Median exposure of all cancer patients was 7.1 PM_2.5 ug/m³ (IQR 6.8-7.3; Range 4.3-65.8). Of the ever smokers, 6.1% had a PM_2.5 >10 ug/m³ whereas 15.1% of the never smokers had a PM_2.5 >10 ug/m³. Among never smokers with lung cancer with high PM_2.5 exposure >10 ug/m³, 74% were female and 83% were of Asian descent. Using a logistic regression model, we demonstrated a significant association between air pollution exposure and never smokers compared to ever smokers in women: Odds Ratio_{per_1_LN-transformed unit} = 12.05 (p<0.001). This association was absent in males (interaction p=0.006).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    In women with lung cancer, outdoor air pollution exposure was significantly higher in never smokers than in ever smokers. This association was not observed in men with lung cancer.

    6f8b794f3246b0c1e1780bb4d4d5dc53

    Information from this presentation has been removed upon request of the author.

    Information from this presentation has been removed upon request of the author.