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Syed Sammar Abbas Zaidi



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    MA07 - Towards Survivorship: The Landscape, Supports and Barriers (ID 904)

    • Event: WCLC 2018
    • Type: Mini Oral Abstract Session
    • Track: Advocacy
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 13:30 - 15:00, Room 205 AC
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      MA07.07 - Identifying the Severity of Psychosocial Symptoms Among Patients Diagnosed with Lung Cancer. Do We Really Need Emotional Support Groups? (ID 13701)

      14:10 - 14:15  |  Author(s): Syed Sammar Abbas Zaidi

      • Abstract
      • Slides

      Background

      Lung cancer is the second most common cancer among men and women. Most of the lung cancers are diagnosed at later stages among those patients who are underprivileged. The diagnosis and treatment of lung cancer is a continuous emotional distress for both patient and their family. We aim to identify the severity of depression, emotional distress, stress and mental fatigue among those patients who are diagnosed with lung cancer .

      a9ded1e5ce5d75814730bb4caaf49419 Method

      A cross sectional study was conducted in Shaukat Khanum Hospital, Lahore from March 2014 to April 2015. Exclusion and Inclusion criteria were made. 150 were enrolled in the study. Socio demographic characteristics were evaluated using Beck Depression Inventory and socio demographic form. Severity of depression was estimated by using Hamilton D (HAM-D). Various variables were analysed including parent’s age, level of education, socioeconomic status, gender and number of children.

      4c3880bb027f159e801041b1021e88e8 Result

      68% of the participants exhibited severe range of depression. 27% showed moderate depression where as 5% participants were showing the mild range of depression. An inverse co relation was found between educational status, occupational status (paid or unpaid), their marital status, socioeconomic family status and depression. Women 71% were found be more depressed than males.

      8eea62084ca7e541d918e823422bd82e Conclusion

      We concluded that majority of patients from psychosocial symptoms particularly depression and it is mainly associated with some factors. There is need to incorporate patients into the diagnosis and treatment process so that we can over come the effects of depression on the health outcomes of patients diagnosed with lung cancer. This can only be possible through appropriate education and emotional support programmes.

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    P2.10 - Prevention and Tobacco Control (Not CME Accredited Session) (ID 959)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.10-16 - Finding the Relations Between Lung Cancer and Associated Risk Factors in Pakistani Population (ID 13688)

      16:45 - 18:00  |  Author(s): Syed Sammar Abbas Zaidi

      • Abstract

      Background

      In Pakistan incidence and mortality rates due to lung cancer are rising with time. Lung cancer is affecting more people than it was before. One of the most common malignancies in world today is lung cancer. Determination of risk factors can help people in preventing this lethal disease. Unfortunately limited data is available on determinants of lung cancer in Pakistani population. Very few studies have been carried out till now. The relationship between various risk factors and lung cancer was evaluated in case control study.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Five hundred lung cancer patients cytological or pathologically diagnosed were enrolled as cases. Nine hundred cancer free people were enrolled as controls. Enrollment was done from different hospitals all across Pakistan. By questionnaire socio-demographic, occupational, lifestyle variables were extracted.

      4c3880bb027f159e801041b1021e88e8 Result

      Odds ratio (ORs) and 95% confidence intervals (95%CI) were calculated & dose response associations were also assessed for suitable factors. Smoking(ORs=8.3,95%CI=6.9-12.8),second hand smoking(ORs=5.1,95%CI=3.5-8.3),diesel exhaust(ORs=4.2,95%CI=3.1-4.5),family history(ORs=2,95%CI=1.6-2.6)previous lung disease(ORs=1.8,95%CI=1.2-2.6).Strongest dose-response relationship was observed for smoking.

      8eea62084ca7e541d918e823422bd82e Conclusion

      The comparison between cases and controls showed that main lung cancer determinants in Pakistan are smoking, second hand smoking, diesel exhaust, family history and previous lung disease. Less exposure to above mentioned factors can decrease the incidence of lung cancer in Pakistani population. Cooking and lung cancer association was not found.

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    P3.CR - Case Reports (Not CME Accredited Session) (ID 984)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.CR-25 - Finding the Ways to Determine the Prognosis of Pulmonary Carcinoids with Certain Genes/Markers in Pakistan (ID 13692)

      12:00 - 13:30  |  Author(s): Syed Sammar Abbas Zaidi

      • Abstract

      Background

      Pulmonary neuroendocrine tumors are classified into four subtypes from well differentiated to poorly differentiated high grade large cell neuroendocrine carcinomas. Because of the difficult histological classification and a cancer free period following surgery, it is often difficult to predict certain prognostic factors. We aim to analyse the prognostic factors of pulmonary carcinoids. In our study we also aim to find the the patterns of CD44, OTP and RET.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      The study was conducted in tertiary care. CD44, OTP and RET were analysed in 70 frozen carcinoids by using PCR. mRNA expression of these genes were assessed. Methylation and mutation analysis was used to assess RET proto oncogene. Immmunohistochemistry for CD44 and protein expression for OTP was conducted

      4c3880bb027f159e801041b1021e88e8 Result

      Downward regulation of CD44 and OTP in carcinoid patients exhibited poor prognosis with distant metastasis whereas the RET was upregulated. This subsequently shows that these genes had a large negative impact on 20-year overall survival. Absence of CD44 was also strongly correlated with distant metastasis A strong positive CD44 effect on patient outcome was observed when membranous staining CD44 was present. We determined that RET expression was not related to promoter methylation or gene mutations. The absence of nuclear OTP followed by complete loss of expression was also significantly associated with unfavorable disease outcome in all carcinoids. Other independent prognostic predictors were also determined

      8eea62084ca7e541d918e823422bd82e Conclusion

      We found that loss of CD44 or OTP expression shows adverse patient outcomes. We conclude that these strong prognostic markers should be implemented in the routine diagnosis so that we can determine the prognosis of pulmonary carncioids

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