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Harvey Pass



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    MA23 - Early Stage Lung Cancer: Present and Future (ID 926)

    • Event: WCLC 2018
    • Type: Mini Oral Abstract Session
    • Track: Treatment of Early Stage/Localized Disease
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/26/2018, 10:30 - 12:00, Room 105
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      MA23.01 - Buffy Coat Immunooncologic Diagnosis and Prognosis of pStage I Lung Adenocarcinoma (Now Available) (ID 12453)

      10:30 - 10:35  |  Presenting Author(s): Harvey Pass

      • Abstract
      • Presentation
      • Slides

      Background

      Accurate diagnosis of CT detected pulmonary nodules is crucial to decrease futile minimally invasive resections. We hypothesize that the circulating cellular microenvironment (buffy coat [BC]) containing granulocytes, mononuclear cells, and platelets presents immunologic transcriptional profiles for distinguishing adenocarcinoma from granulomas, and can prognosticate pStage I adenocarcinomas.

      Method

      BC total RNA was extracted from 48 pStage I adenocarcinomas having R0 resection and 23 granuloma patients found at surgery. Of the cancers, 23 did not recur either systemically or locoregionally and were matched by age, gender, and pack-years to progressors. RNA was profiled using Nanostring PanImmune Oncology panel for 770 immune genes and cytokines. A machine learning algorithm based on Elastic Net using 1000 loops of cross validation was run to estimate AUC, and logistic regression models used for prognostic classification.

      Result

      wclc 18 final.pngThe figure depicts the results of the diagnostic profiling in the upper panel (A-C), and prognostication in lower panel (D-F). Unsupervised heat map separated adenocarcinomas (grey) from granulomas, and among the gene set analysis, differences in interleukins, microglial function, antigen processing, cytokines and macrophage functions were the most significant for cohort discrimination. A 33 gene set signature was able to separate granuloma from cancer with mean AUCs of 0.982. Expresion of BC immune related genes were remarkably different between the patients who recurred, and there were differences in profiles of locoregional recurrences compared to systemic recurrences (data not shown).Patients with elevated T-regs but decreased T-cells were characterized by distant progression, while decreased mast cells and increased CD-8 and total T-cells were associated with local recurrence. A three step prognostication index using 19 genes could stratify these patients by time to progression (E,F).

      Conclusion

      These encouraging data offer the potential for immune transcriptional signatures to better select patients for diagnosis/management of early stage adenocarcinoma. Further validation studies are underway for possible presentation at WCLC18.

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    MS25 - Genetic and Prognostic Markers in Mesothelioma; Going Beyond the Histology Subtypes (ID 803)

    • Event: WCLC 2018
    • Type: Mini Symposium
    • Track: Mesothelioma
    • Presentations: 1
    • Now Available
    • Moderators:
    • Coordinates: 9/26/2018, 10:30 - 12:00, Room 206 AC
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      MS25.04 - Biomarkers in Clinical Practice: Is It Prime Time? (Now Available) (ID 11509)

      11:15 - 11:30  |  Presenting Author(s): Harvey Pass

      • Abstract
      • Presentation
      • Slides

      Abstract not provided

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    WS02 - Mesothelioma Workshop (ID 996)

    • Event: WCLC 2018
    • Type: Workshop
    • Track: Mesothelioma
    • Presentations: 2
    • Now Available
    • Moderators:
    • Coordinates: 9/23/2018, 08:00 - 11:15, Room 205 AC
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      WS02.01 - Session 1: Surgery for Mesothelioma (Now Available) (ID 14745)

      08:00 - 08:00  |  Presenting Author(s): Harvey Pass

      • Abstract
      • Presentation

      Abstract not provided

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      WS02.03 - Who Are the High Risk Patients for Surgical Failure in Mesothelioma? (Now Available) (ID 14747)

      08:15 - 08:30  |  Presenting Author(s): Harvey Pass

      • Abstract
      • Presentation
      • Slides

      Abstract not provided

      Only Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login, select "Add to Cart" and proceed to checkout. If you would like to become a member of IASLC, please click here.

      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.