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J.S. Eom

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    Poster Display session (Friday) (ID 65)

    • Event: ELCC 2018
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/13/2018, 12:30 - 13:00, Hall 1
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      226P - Accuracy of mutation analysis in small tissues from transbronchial lung biopsy with radial probe endobronchial ultrasound (ID 437)

      12:30 - 13:00  |  Author(s): J.S. Eom

      • Abstract

      There is little evidence to support the reliability of molecular analysis using transbronchial lung biopsy combined with radial probe endobronchial ultrasound and a guide sheath (EBUS-GS) specimens. In order to verify the accuracy of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) gene rearrangement results using EBUS-GS specimens, we conducted a retrospective study using a prospectively collected database.

      From December 2015 to May 2017, consecutive patients who received EBUS-GS for the diagnosis of peripheral lung nodule or mass were registered. For the comparisons of EGFR mutation and ALK gene rearrangement analysis using EBUS-GS specimen, molecular analysis using surgical specimen was considered as gold standard. As a result, 70 patients who received both EBUS-GS and subsequent surgical treatment were included.

      Using surgical specimens, EGFR mutation and ALK gene rearrangement were detected in 37% and 4%, respectively. In comparisions with reference value, the accuracy of EGFR mutation and ALK gene rearrangement correlations analysis of using EBUS-GS specimens were revealed as 97% and 100%, respectively.

      The present study demonstrated that the molecular studies, such as EGFR mutation and ALK rearrangement analysis, with the EBUS-GS specimen were reliable comparing with those using surgical specimen.

      Clinical trial identification:

      Legal entity responsible for the study:
      Pusan National University Hospital

      Has not received any funding

      All authors have declared no conflicts of interest.