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Poster Display session (Friday) (ID 65)
- Event: ELCC 2018
- Type: Poster Display session
- Presentations: 1
- Coordinates: 4/13/2018, 12:30 - 13:00, Hall 1
226P - Accuracy of mutation analysis in small tissues from transbronchial lung biopsy with radial probe endobronchial ultrasound (ID 437)
12:30 - 13:00 | Author(s): J.S. Eom
There is little evidence to support the reliability of molecular analysis using transbronchial lung biopsy combined with radial probe endobronchial ultrasound and a guide sheath (EBUS-GS) specimens. In order to verify the accuracy of epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) gene rearrangement results using EBUS-GS specimens, we conducted a retrospective study using a prospectively collected database.
From December 2015 to May 2017, consecutive patients who received EBUS-GS for the diagnosis of peripheral lung nodule or mass were registered. For the comparisons of EGFR mutation and ALK gene rearrangement analysis using EBUS-GS specimen, molecular analysis using surgical specimen was considered as gold standard. As a result, 70 patients who received both EBUS-GS and subsequent surgical treatment were included.
Using surgical specimens, EGFR mutation and ALK gene rearrangement were detected in 37% and 4%, respectively. In comparisions with reference value, the accuracy of EGFR mutation and ALK gene rearrangement correlations analysis of using EBUS-GS specimens were revealed as 97% and 100%, respectively.
The present study demonstrated that the molecular studies, such as EGFR mutation and ALK rearrangement analysis, with the EBUS-GS specimen were reliable comparing with those using surgical specimen.
Clinical trial identification:
Legal entity responsible for the study:
Pusan National University Hospital
Has not received any funding
All authors have declared no conflicts of interest.