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N. Corsini



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    Poster Display session (Friday) (ID 65)

    • Event: ELCC 2018
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/13/2018, 12:30 - 13:00, Hall 1
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      185P - Retrospective study of tumour responses and toxicities associated with anti-PD1 antibody therapy in elderly cancer patients(>75yo) in comparison to patients ≤75yo with metastatic non-small cell lung cancer (ID 324)

      12:30 - 13:00  |  Author(s): N. Corsini

      • Abstract
      • Slides

      Background:
      Antibodies directed against PD1 (anti PD1) are approved in Australia for the second line treatment of metastatic non-small cell lung cancer (met NSCLC). There is limited data on the efficacy and tolerability of anti-PD1 in elderly cancer patients. The purpose of this study was to retrospectively evaluate the responses and toxicities in elderly (>75yo) compared with younger patients (≤ 75yo) with met NSCLC treated with anti-PD1.

      Methods:
      56 patients (36 patients ≤75yo; 20 patients >75yo) with metastatic non-small cell lung carcinoma treated with anti-PD1 at Royal Adelaide Hospital, Australia, between January 2010 to January 2017 were retrospectively identified. Patient demographics, metastatic non-small cell lung cancer characteristics, response rates, toxicity profiles and survival data were collected. Statistical comparisons were made between the older (>75yo) and younger (≤75yo) patients.

      Results:
      Adenocarcinoma was the most common histological type of non-small cell lung cancer in both groups. Patients that achieved stable disease in ≤75yo (20/36, 55.6%) were slightly lower compared with >75yo (15/20, 75%). Patients that progressed on anti-PD1 were higher in ≤75yo (12/36, 33.3%) compared with >75yo (5/20, 25%). Median overall survival (OS) and progression-free survival (PFS) was 8.0 months (95% CI, 0.00 to 16.6 months) and 5.0 months (95% CI, 1.47 to 8.53 months), respectively, in the ≤75yo group and 20.0 months (95% CI, 9.2 to 30.8 months) and 6.0 months (95% CI, 4.55 to 7.45 months), respectively, in the >75yo. The log-ranked test indicates that the survival distributions do not differ for OS or PFS (OS, p = .88 and PFS, p > .05). The rates of adverse events were similar between both groups with the most common adverse event being rash and fatigue (grade 1–2). Anti-PD1 treatment discontinuation occurred in 26/36 (72.2%) of ≤75yo and 17/20 (85%) of >75yo. Main reason for treatment discontinuation was progression of disease, 23/36 (63.9%) of ≤75yo and 15/20 (75%) of >75yo.

      Conclusions:
      Anti-PD1 antibodies are safe and effective in elderly patients with metastatic non-small cell lung cancer. Response rate and toxicity profiles are similar between ≤75yo and >75yo.

      Clinical trial identification:


      Legal entity responsible for the study:
      Authors

      Funding:
      Has not received any funding

      Disclosure:
      All authors have declared no conflicts of interest.

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