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N. Lukavetskyy



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    Poster Display session (Friday) (ID 65)

    • Event: ELCC 2018
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/13/2018, 12:30 - 13:00, Hall 1
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      97P - Multistep prediction of cardio-pulmonary morbidity after lung cancer surgery (ID 558)

      12:30 - 13:00  |  Presenting Author(s): N. Lukavetskyy

      • Abstract

      Background:
      The aim of the study is to establish “multistep” criteria to clarify the high-risk patients with resectable lung cancer. The purpose of the present study was to identify preoperative risk factors in lung cancer patients.

      Methods:
      Retrospective review of the clinical records of all patients operated on thoracic department in 2010–2011. None of the patient received preoperative chemo and/or-radiotherapy. Patients older than 70 years, benign lung lesions, lung metastases, or patients after non-curative lung resection were excluded. A total of 168 patients met criteria for the study. All factors were divided into 3 groups: initial (36 factors incl. TNM, histology, presence of comorbidities etc), functional (29 factors – lung function parameters, echocardiography), and surgery-related (14 factors incl. type of surgery and lymphadenectomies etc.). We analyzed postoperative mortality, pulmonary complications, arrhythmia and hypertension. All of the variables that were found to be significant in the univariate analyses were entered into the multivariate analyses using a forward step-wise logistic regression model in all group separately.

      Results:
      Group 1. Our model identifies no risk factors for postoperative mortality and hypertension. Diabetes mellitus is associated with higher rates of arrhythmia. Predictors that are associated with pulmonary complication include: the history of second primary cancer, neuroendocrine tumours, rare type of lung tumours. Group 2. There are no risk factors for arrhythmia and hypertension. Left ventricular ejection fraction <45 is associated with postoperative mortality, forced expiratory flow at 25% – pulmonary complication. Group 3. The following criteria related with postoperative mortality – number of unobstructed (by tumours) lung segments, pulmonary complications – ventilation time, arrhythmia – number of resected lymph nodes, hypertension – surgery with resection adjacement structures.

      Conclusions:
      There are risk factors associated with higher rates of specific postoperative mortality and morbidity but need to be validated by prospective study.

      Clinical trial identification:


      Legal entity responsible for the study:
      Lviv Medical University

      Funding:
      Has not received any funding

      Disclosure:
      All authors have declared no conflicts of interest.