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T. Tian



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    Poster Display session (Friday) (ID 65)

    • Event: ELCC 2018
    • Type: Poster Display session
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 4/13/2018, 12:30 - 13:00, Hall 1
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      44P - A large population-based study on large cell neuroendocrine lung cancer: A SEER database analysis (ID 293)

      12:30 - 13:00  |  Author(s): T. Tian

      • Abstract

      Background:
      Large cell neuroendocrine lung cancer (LCNELC) is a subtype of lung cancer with neuroendocrine morphology and differentiation on immunohistochemistry, a high mitotic rate and non-small cell cytological features. However large population-based study on the clinicalpathological characteristics of LCNELC is lacking. Nomogram provides a visualized equation that the behavior of a predictor is represented in scales. In this study, we aim to explore the potential associations between clinicopathological factors and prognosis in SEER-18 database and to establish a nomogram model to predict the prognosis of LCNELC.

      Methods:
      We used the SEER-18 database to study the prognosis of LCNELC patients from 2000 to 2014 in the United States. All statistical analyses were performed by R software. We used packages “SEERaBomb”, “survival”, “rms”, and “rcorrp.cens” to obtain data and to build and evaluate the nomogram.

      Results:
      A total number of 1231 patients were enrolled. Sex, marital status, age at diagnosis, tumor size, AJCC TNM stage, and SEER histologic stage affect the prognosis of LCNELC patients. We included these factors to develop the nomogram prediction model. The Harrel's C-index showed that the nomogram model has a better prediction than traditional AJCC TNM staging system. We evaluated different surgeries for patients at early and advanced TNM stages as well as different SEER histologic stages, and suggested that early TNM stage or localized and regional SEER histologic stages patients benefit from surgical resection, especially lobectomy or bilobectomy.

      Conclusions:
      Age, sex, marital status, tumor size, TNM stage, SEER histologic stage, and both radiation and surgery treatment are independent prognostic variants for LCNELC. And early TNM stage or localized and regional SEER stage of LCNELC patients benefit from surgical resection, especially lobectomy or bilobectomy.

      Clinical trial identification:


      Legal entity responsible for the study:
      The First Affiliated Hospital of Xi'an Jiaotong University

      Funding:
      Natural Science Foundation of Shaanxi Province (No.2017JM8019). International cooperation project in science and technology of Shaanxi province (No. 2016KW-017). Wu Jieping Medical Foundation (No. 50603020).

      Disclosure:
      All authors have declared no conflicts of interest.