Author of

• 25520

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  Poster Display session (Friday) (ID 65)

  • Event: ELCC 2018
  • Type: Poster Display session
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 4/13/2018, 12:30 - 13:00, Hall 1

  • 25245

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    15P - Comprehensive profiling of lincRNAs in lung adenocarcinoma of never smokers reveals their important roles in cancer development and prognosis (ID 362)

    12:30 - 13:00  |  Author(s): X. Zhang
    • Abstract

    Background:
    Long intergenic non-coding RNA (lincRNA) is a family of gene transcripts whose functions are largely unknown in disease process. Although cigarette smoking is the main cause of lung cancer, lung cancer in never smokers is a separate entity and its underlying cause is little known. Growing evidence suggests lincRNAs play a significant role in cancer development and progression; however, such data is lacking for lung cancer in never-smokers.
    
    Methods:
    This study conducted comprehensive profiling of lincRNAs from RNA-seq data in 27 pairs of lung adenocarcinoma and its normal tissues of never smokers. Both known and novel lincRNAs segregated tumors from normal tissues clearly. About a third of lincRNAs were differentially expressed between tumors and normal samples and most of them were coordinated with their putative protein gene targets. More interestingly, lincRNAs defined two clusters of tumors that were associated with tumor aggressiveness and patient survival.
    
    Results:
    We identified a subset of lincRNAs that were differentially expressed but also associated with patient survival. Almost perfect concordance was observed for differentially expressed lincRNAs and lincRNAs associated with survival from the discovery set were also predictive for survival in the validation set of 85 transcriptomes.
    
    Conclusions:
    With further validation, these lincRNAs could serve as potential diagnostic and prognostic markers.
    
    Clinical trial identification:
    
    
    Legal entity responsible for the study:
    Mayo Clinic
    
    Funding:
    The National Natural Science Foundation of China (No.81472835)
    
    Disclosure:
    All authors have declared no conflicts of interest.