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Isabelle Opitz
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P2.06 - Mesothelioma (Not CME Accredited Session) (ID 955)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 2
- Moderators:
- Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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P2.06-13 - Poor Nutritional Status Is a Poor Prognostic Factor in Malignant Pleural Mesothelioma (ID 12201)
16:45 - 18:00 | Author(s): Isabelle Opitz
- Abstract
Background
To investigate the clinical meanings of nutritional status in malignant pleural mesothelioma (MPM).
a9ded1e5ce5d75814730bb4caaf49419 Method
We retrospectively reviewed 87 MPM patients intended to be treated within a multimodality treatment (MMT) concept between September 1999 and April 2017. We used the prognostic nutritional index (PNI) to evaluate the nutritional status; serum albumin (g/l) + 5 × lymphocyte (G/L) in peripheral blood. Primary endpoint of this study was to investigate the correlation between PNI and overall survival (OS), and secondary endpoint was to investigate the association between PNI and completion rate of MMT.
4c3880bb027f159e801041b1021e88e8 Result
Of 87 enrolled patients, 61 (70.1%) patients were completed MMT. Median pretreatment PNI was 45.1 (range: 24.5–58.8). We divided this cohort into Low-PNI group (PNI < 45, n=42) and High PNI group (PNI >= 45, n=45). The completion rate of MMT was significantly higher in High PNI group than Low (82.2% vs 57.1%, p=0.018). On survival analyses, Low PNI group had significantly (p=0.004) shorter median OS than High PNI group (12.0 vs 21.3 months, p=0.004). In multivariate analysis using Cox regression model, which showed Low PNI had increased the risk of death compared with High-PNI (HR: 2.64; 95%CI, 1.32-5.28; p=0.006), as well as elevated C-reactive protein (HR: 20.8; 95%CI, 1.17-3.70; p=0.012).
8eea62084ca7e541d918e823422bd82e Conclusion
Pretreatment PNI is a novel prognostic factor in MPM patients intended to be treated within MMT concept. Low PNI was significantly associated with low completion rate of MMT.
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P2.06-22 - Proposal of a New Local Recurrence Score for Patients with Malignant Pleural Mesothelioma (ID 13486)
16:45 - 18:00 | Author(s): Isabelle Opitz
- Abstract
Background
Malignant pleural mesothelioma (MPM) is associated with high rates of local recurrence (LR) up to 75%. Second line treatment should be applied tailored to relapse pattern. The aim of the present study was to establish a new score for LR pattern with prognostic and treatment impact.
a9ded1e5ce5d75814730bb4caaf49419 Method
From 2001 until 2017, 165 consecutive MPM patients with LR after macroscopic complete resection either by extrapleural pneumonectomy (EPP) or (extended) pleurectomy/decortication ((e)P/D) were enrolled in this retrospective study. Due to missing data 37 patients were excluded from analysis. Further analysis was done with remaining 128 patients (EPP: n=61 and eP/D: n=67). We divided the thoracic cavity into the following sections: chest wall (CW), mediastinum (Med), diaphragm (Di), lung parenchyma (LP), neo-pleural thickening (N-PT) and lymph node (LN) (Figure 1A). We assessed the prognostic impact of local recurrence score (LRS=size ((Measurement of perpendicular diameter)) of recurrence sites multiplied by the number of LR sites) using cox regression model.
4c3880bb027f159e801041b1021e88e8 Result
The frequency of the location was as follows; CW 47.7%, Di 24.2%, Med 38.3%, N-PT 61.7%, LP 25.0% and LN 55.5% (Figure 1B). The median LRS was 4 (range: 1-12). Low LRS (<= 4) was significantly correlated with longer survival after LR (low score 16.4 vs high score 9.8 months, p=0.03). Of 6 locations, first recurrence at CW (negative 16 vs positive 9.8 months, p=0.044) and LN (negative 17.2 vs positive 9.2 months, p=0.015) had significant negative prognostic impact on OS. In subgroup analysis, LRS was significantly higher after eP/D compared to EPP (median LRS: 6 vs 4, p<0.001), but survival after LR was significantly longer after eP/D compared to EPP (14.6 vs 9.6 months, p=0.004).
8eea62084ca7e541d918e823422bd82e Conclusion
LRS might be a useful prognosticator in MPM patients with LR after MMT and might be helpful for further use as second line treatment allocation tool.
6f8b794f3246b0c1e1780bb4d4d5dc53
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PC01 - Controversies in Mesothelioma (ID 840)
- Event: WCLC 2018
- Type: Pro-Con Session
- Track: Mesothelioma
- Presentations: 1
- Moderators:
- Coordinates: 9/24/2018, 10:30 - 12:00, Room 205 AC
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PC01.01 - PRO Intrapleural Chemotherapy Is It the Future? (ID 11598)
10:30 - 10:45 | Presenting Author(s): Isabelle Opitz
- Abstract
- Presentation
Abstract not provided
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