Author of

• 20169

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  P2.05 - Early Stage NSCLC (ID 706)

  • Event: WCLC 2017
  • Type: Poster Session with Presenters Present
  • Track: Early Stage NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)

  • 23357

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    P2.05-014 - Factors Associated with Recovery Time to Predicted FEV1 in Non-Small-Cell Lung Cancer Patients after Lobectomy (ID 9212)

    09:30 - 16:00  |  Author(s): H.W. Kim
    • Abstract

    Background:
    Long term pulmonary function after lung resection is related with quality of life in patients with lung cancer. Previous studies found that impaired pulmonary function persisted for at least 3 months after lung resection followed by gradual restoration, time-dependent improvement. This study aimed to identify factors associated with delayed recovery to predicted FEV1 calculated with perfusion scan or segment counting method in non-small-cell lung cancer patients after lobectomy.
    
    Method:
    Medical records of seventy-four patients with non-small-cell lung cancer who underwent lobectomy and preoperative perfusion scan was retrospectively reviewed. Achieving 100% of predicted FEV1 calculated with perfusion scan was defined as event, and time to event was analyzed with parametric survival model with Weibull distribution handling interval censored data. Another survival model was elucidated with definition of the event as achieving 100% of predicted FEV1 calculated with segment counting method.
    
    Result:
    In a multivariable survival model (Perfusion scan), LUL lobectomy had shorter accelerated failure time value compared with RUL lobectomy (p=0.0328), and ‘Adjuvant chemotherapy before event’ had longer accelerated failure time value (p=0.0202) after adjusting the variable ‘CTD indwelling duration after operation more than 10 days’. In another multivariable survival model (segment counting method), LUL lobectomy had shorter accelerated failure time value compared with RUL lobectomy (p<0.001), and ‘Adjuvant chemotherapy before event’ had longer accelerated failure time value (p=0.034) after adjusting the variable ‘CTD indwelling duration after operation more than 10 days’ and ‘pneumonia within 1 month after operation’.
    
    Conclusion:
    LUL lobectomy showed faster recovery to predicted FEV1 than RUL or RML lobectomy. Adjuvant chemotherapy had delayed recovery to predicted FEV1.