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B. Wang
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P1.14 - Radiotherapy (ID 700)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Radiotherapy
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.14-010 - SGA Could Be a Predictive Factor for Radiation Pneumonitis in Lung Cancer Patients Treated by Concurrent Chemoradiotherapy (ID 8080)
09:30 - 16:00 | Author(s): B. Wang
- Abstract
Background:
To investigate the relationship between malnutrition and the severity of radiation pneumonitis (RP) in lung cancer patients with normal baseline pulmonary function and lungs’ V20<35% treated by intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy.
Method:
One hundred and fifty patients with lung caner who received definitive IMRT (≥60 Gy) and concurrent chemotherapy were enrolled. In the condition of normal baseline pulmonary function and strict constraints of the irradiation dose to normal lung tissues, we recorded Eastern Cooperative Oncology Group (ECOG) score, concurrent chemotherapy, clinical stage, the level of albumin (ALB), hemoglobin and C-reactive protein (CRP), Subjective Global Assessment (SGA) scores and radiation esophagitis (RE) grade. These factors were correlated with RP using univariate and multivariate regression analyses.
Result:
Of 150 patients, 12 patients (8.0%) developed Grade 3–5 RP, 37 (24.6%) patients developed Grade 3–5 esophageal toxicity. In univariate analysis, ALB level (p = 0.002), RE (p < 0.001) and SGA score (p < 0.001) were significantly associated with RP. Multivariate analysis revealed that SGA (p < 0.001) was the independent predictor of RP.
Conclusion:
SGA could be a predictor for RP in lung cancer patients treated with definitive IMRT and concurrent chemotherapy.
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P2.14 - Radiotherapy (ID 715)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Radiotherapy
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.14-004 - Comparable Local Controls after Twice-Daily and Once-Daily Chest Radiotherapy in Extensive Stage Small Cell Lung Cancer (ID 8788)
09:30 - 16:00 | Author(s): B. Wang
- Abstract
Background:
The optimal radiation schedule for small cell lung cancer (SCLC) has not yet fully established. This study was designed to compare the clinical outcomes between twice- and once-daily radiotherapy in the treatment of SCLC.
Method:
One hundred and twenty-four consecutive patients diagnosed with extensive stage SCLC and treated with chemoradiotherapy were retrospectively reviewed. Either twice-daily hyper-fractionated irradiation (45 Gy/30 fractions/BID), or alternative schedules, including hypo-fractionated (45 Gy/15 fractions/QD) or conventionally fractionated (50 Gy/25 fractions/QD or 60 Gy/30 fractions/QD) radiation was delivered, with etoposide and platinum prescribed concurrently or sequentially. Local controls and overall survivals were calculated and compared between twice- and once-daily schedules based on Kaplan-Meier method. Toxicities were record according to Common Terminology Criteria Adverse Events.
Result:
There were 67 and 57 patients received twice- and once-daily chest radiotherapy, respectively. With a median follow-up of 27 and 24 months, the local control rates were reported 64.2% and 63.2%. The 2-year estimated local progression-free survival rates were similar (61.6% vs 61.0%, p=0.90). Progressive disease identified three months after radiotherapy was correlated to increased local failure (p=0.026). There was no difference between the incidences of grade 3-4 toxicities between twice- and once-daily schedules (23.9% vs 12.3%, p=0.16).
Conclusion:
Either twice- (45 Gy/30 fractions/BID) or once-daily (45 Gy/15 fractions/QD, 50 Gy/25 fractions/QD, 60 Gy/30 fractions/QD) radiation schedule could be considered in the treatment of SCLC, resulting in comparable local control and toxicities.
