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L. Ma
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P1.14 - Radiotherapy (ID 700)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Radiotherapy
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.14-010 - SGA Could Be a Predictive Factor for Radiation Pneumonitis in Lung Cancer Patients Treated by Concurrent Chemoradiotherapy (ID 8080)
09:30 - 16:00 | Author(s): L. Ma
- Abstract
Background:
To investigate the relationship between malnutrition and the severity of radiation pneumonitis (RP) in lung cancer patients with normal baseline pulmonary function and lungs’ V20<35% treated by intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy.
Method:
One hundred and fifty patients with lung caner who received definitive IMRT (≥60 Gy) and concurrent chemotherapy were enrolled. In the condition of normal baseline pulmonary function and strict constraints of the irradiation dose to normal lung tissues, we recorded Eastern Cooperative Oncology Group (ECOG) score, concurrent chemotherapy, clinical stage, the level of albumin (ALB), hemoglobin and C-reactive protein (CRP), Subjective Global Assessment (SGA) scores and radiation esophagitis (RE) grade. These factors were correlated with RP using univariate and multivariate regression analyses.
Result:
Of 150 patients, 12 patients (8.0%) developed Grade 3–5 RP, 37 (24.6%) patients developed Grade 3–5 esophageal toxicity. In univariate analysis, ALB level (p = 0.002), RE (p < 0.001) and SGA score (p < 0.001) were significantly associated with RP. Multivariate analysis revealed that SGA (p < 0.001) was the independent predictor of RP.
Conclusion:
SGA could be a predictor for RP in lung cancer patients treated with definitive IMRT and concurrent chemotherapy.
