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S. Bhuniya

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    P1.02 - Biology/Pathology (ID 614)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Biology/Pathology
    • Presentations: 1
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      P1.02-066 - Cancer Stem Cells  in Pulmonary High Grade Neuroendocrine Carcinoma: a Series of 23 Cases from Eastern India (ID 9719)

      09:30 - 16:00  |  Author(s): S. Bhuniya

      • Abstract

      As per WHO 2015 classification, high grade neuroendocrine carcinomas (HGNEC) [both large cell (LCNEC) and small cell (SCLC)] constitute around 20% of the total lung carcinomas. These tumours are biologically aggressive with early metastasis; have a tendency to recur and develop resistance to conventional chemotherapy. The aggressive behaviour is postulated to be due to the presence of stem cell like cancer cells [cancer stem cell (CSC)].This study was aimed to determine the clinicopathological significance of CSC markers in HGNEC on small lung biopsies.

      Twenty three cases of HGNEC (7 LCNEC, 16 SCLC) diagnosed over a period of 2 ½ years at AIIMS, Bhubaneswar were analysed retrospectively. Bronchoscopic and transthoracic biopsies were subjected to routine morphological and immunohistochemical analysis by using synaptophysin, chromogranin, CD 56/NCAM, and Mib-1. Subcategorization was done as per WHO 2015 guidelines. CSC markers such as ALDH1, CD 34, and CD 117 were used for further analysis.

      As followsFigure 1 Figure 2

      A high proportion (16/23, 68%) of HGNECs were positive for at least one CSC marker. ALDH1 expression noted more in LCNEC. Immunohistochemical expression of CSC markers on small biopsies may be used for prognostication and management in pulmonary neuroendocrine carcinomas.