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P1.02 - Biology/Pathology (ID 614)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
P1.02-020 - Acinar-Predominant Pattern Correlates with Poorer Prognosis in Invasive Mucinous Adenocarcinoma of the Lung (ID 7928)
09:30 - 16:00 | Author(s): C. Xie
Invasive mucinous adenocarcinoma (IMA) is a variant of lung adenocarcinoma. Growth pattern such as lepidic, acinar, papillary and micropapillary can be seen in IMA. However, no study regarding prognostic and clinicopathologic aspects of IMAs with different growth pattern has been reported.
From January 1999 to July 2011, of 2236 patients with newly diagnosed primary lung adenocarcinoma, 16 patients were identified as lepidic-predominant IMA and 10 patients as acinar-predominant IMA. Data regarding the clinicopathological characteristics, CT features and prognosis was collected.
No statistically significant difference was noted in gender, age as well as smoker proportion between lepidic-predominant and acinar-predominant IMA. There was no statistically significant difference in T classification. The proportion of lymph node metastasis was significantly higher in acinar-predominant IMA (P=0.046). Both the tumors shared many signs in CT findings. Air-bronchgram was a relatively specific sign for lepidic-predominant IMA. Survival analysis showed that lepidic-predominant IMA also have a more favorable outcome than acinar-predominant IMA (P=0.0294). Figure 1Figure 2
Lepidic-predominant and acinar-predominant IMA are two different subtypes of IMA. Acinar-predominant IMA is associated with lymph node metastasis and has a poorer prognosis than lepidic-predominant IMA.