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Ryosuke Chiba
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P2.06 - Epidemiology/Primary Prevention/Tobacco Control and Cessation (ID 707)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Epidemiology/Primary Prevention/Tobacco Control and Cessation
- Presentations: 1
- Moderators:
- Coordinates: 10/17/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P2.06-009 - Trace Elements Affect Lung Cancer Subtypes (ID 10282)
09:30 - 16:00 | Presenting Author(s): Ryosuke Chiba
- Abstract
Background:
The cause and mechanism of lung cancer in “never smokers” are still unclear. Additionally, the onset of driver mutations (e.g., EGFR, ALK, KRAS, and RET) and the mechanism of their ethnic difference are unclear. Several studies have suggested that some trace elements may affect the onset of lung cancer. However, the effect of trace elements on lung cancer carcinogenesis is poorly understood. The aim of this study was to assess if trace elements may be the cause of carcinogenesis in lung cancer tissues of patients with lung cancer with a non-smoking history, driver mutations, or histology.
Method:
The study included patients with non-small cell lung cancer who had undergone surgical resection. For the measurement of trace elements, surgically resected formalin-fixed paraffin-embedded lung cancer samples were studied using particle induced X-ray emission analysis. In total, 54 elements were investigated in each sample. EGFR mutation, KRAS mutation, and ALK rearrangement were assessed using commercially available CLIA testing. Based on the pathology and driver mutation status, samples were classified into the following groups: lung adenocarcinoma (LADC) with EGFR mutation (LADC EGFRm+); LADC with KRAS mutation (LADC KRASm+); LADC without EGFR mutation, KRAS mutation, and ALK rearrangement (LADC wt); and lung squamous cell carcinoma (SCC). Tissues from 20 patients with a non-malignant disease (e.g., pneumothorax) were also analyzed for trace elements as controls.
Result:
In total, 80 patients with non-small cell lung cancer were included. The median patient age was 70years. Of the 80 patients, 30 (37.5%) were males and 72 (90%) had stage I/II disease. The levels of 6 trace elements were increased in the LADC wt group. Copper was increased in the LADC EGFRm+ group. Cobalt and zinc were increased in the LADC KRASm+ group. There were no differences in trace element levels between the SCC group and the control group.
Conclusion:
Trace elements may play a role in the pathology and molecular signature of lung cancer.
