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Hiroshi Kobayashi



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    P1.07 - Immunology and Immunotherapy (ID 693)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Immunology and Immunotherapy
    • Presentations: 1
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      P1.07-044b - Pretreatment Neutrophil/Lymphocyte Ratio and the Efficacy of Nivolumab Treatment in Non–Small-Cell Lung Cancer (ID 9375)

      09:30 - 16:00  |  Presenting Author(s): Hiroshi Kobayashi

      • Abstract
      • Slides

      Background:
      The blood neutrophil/lymphocyte ratio (NLR) before ipilimumab administration is a useful predictive biomarker in the treatment of malignant melanoma. However, few studies have evaluated whether NLR can predict and overall survival in non–small-cell lung cancer (NSCLC).

      Method:
      We studied 38 patients with previously treated advanced NSCLC who had received nivolumab therapy between January 2016 and May 2017 at our hospital. Patients were divided into two groups (pretreatment NLR <5 or ≥5), and patient characteristics, treatment effect, adverse events, and immunohistochemical expression of programmed death ligand 1 (PD-L1) were evaluated in both groups.

      Result:
      Of the 38 patients, 12 had an NLR ≥5 and 26 had an NLR <5. Regarding patient characteristics, median PD-L1 expression on immunohistochemistry was significantly higher in the NLR <5 group than in the NLR ≥5 group (38.2% vs 1.7%, respectively; p = 0.049). The objective response rate was 39.1% vs 12.5%, respectively (p = 0.17), and the disease control rate was 95.7% vs 25%, respectively (p <0.001). The disease control rate significantly differed between groups, as did progression-free survival (median progression-free survival: 132 days in the NLR <5 group vs 49 days in the NLR ≥5 group; p = 0.009).

      Conclusion:
      Among patients treated with nivolumab for NSCLC, disease control rate and progression-free survival were better for patients in the NLR <5 group than for those in the NLR ≥5 group. The association between pretreatment NLR and immunohistochemical PD-L1 expression warrants further study.

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    P2.01 - Advanced NSCLC (ID 618)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Advanced NSCLC
    • Presentations: 1
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      P2.01-010 - Risk Score for Predicting Acute Exacerbation after Chemotherapy in Lung Cancer Associated with Interstitial Pneumonia (ID 8094)

      09:00 - 16:00  |  Author(s): Hiroshi Kobayashi

      • Abstract
      • Slides

      Background:
      Fatal acute exacerbation (AE) of interstitial pneumonia (IP) may occur after chemotherapy for lung cancer. We developed and evaluated a scoring system for assessing the risk of AE after chemotherapy in patients with lung cancer associated with IP.

      Method:
      A review of medical records identified 107 patients with primary lung cancer associated with IP who had received chemotherapy during the period from June 2007 through September 2017. We developed a model to scoring AE risk after chemotherapy in lung cancer patients with IP, and logistic regression was used to evaluate this model.

      Result:
      The general score for anti-cancer agents was determined by using rates of AE reported in past studies. The risk score was calculated by using the following formula: (1 × anti-cancer agent general score) + (3 × smoking history [>70 pack-years]) + (4 × history of steroid medication) + (3 × %diffusing capacity of the lung carbon monoxide [<50%]). Patients were then classified into three groups. The AE rate was 12% for a risk score of 0–5, 47% for a score of 6–10, and 66.7% for a score ≥11. This sensitivity of the scoring system was 78.6%, and specificity was 67.8%.

      Conclusion:
      The present scoring system could identify IP patients at high risk for AE after chemotherapy for lung cancer.

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