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Fumi Ohsawa
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P1.02 - Biology/Pathology (ID 614)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Biology/Pathology
- Presentations: 1
- Moderators:
- Coordinates: 10/16/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P1.02-031 - Clinicopathological Study of 16 Cases with Pulmonary Pleomorphic Carcinoma (ID 9334)
09:30 - 16:00 | Presenting Author(s): Fumi Ohsawa
- Abstract
Background:
Pulmonary pleomorphic carcinoma is a rare histologic type with poor prognosis, proposed in the third edition of the 1999 WHO histologic classification of lung tumors.
Method:
We performed surgical treatment for 16 cases with pulmonary pleomorphic carcinoma between April 2000 and April 2017, and investigated the patients’ characteristics and perioperative outcomes.
Result:
The male-to-female ratio was 14 to two. The median age was 68 years, ranging from 55 to 88. All cases had a smoking habit. The locations of tumors were RUL in 5 cases, RML in 3, RLL in 4, LUL in 4 and LLL in 2. Pathological stages were IA2 in1, IA3 in 1, IB in 2, IIA in 3, IIB in 1, IIIA in 6 and IIIB in 2, based on eighth of the TNM classification for lung cancer. Nodal status was classified as pN0 in 11, pN1 in 1 and pN2 in 4. Epithelial components were squamous cell carcinoma in 5 (31%), adenocarcinoma in 5 (31%), double-cell components in 2 (12.5%), no epithelial components in 2 (12.5%) and indistinct in 2 (12.5%), while sarcomatous elements, spindle cells in 8 (50%), giant cells in 1 (6%), double-cell elements in 5 (31%) and indistinct in 2 (13%). Eight cases received adjuvant treatments, including chemotherapy in 5, radiotherapy in 1 and chemoradiotherapy in 2. Postoperative recurrence was detected in 9 cases (56%). And 7 of the nine cases had the recurrence within 6 months after the surgical resection. On the contrary, no recurrence was detected in 7 cases comprised of pN0 in 5 cases and pN1-2 in 2. And 2 of the 7 cases have been disease-free for more than two and a half years.
Conclusion:
Although pulmonary pleomorphic carcinoma has poor prognosis, patients without lymph node metastasis have the possibility of having favorable prognosis compared to the patients with lymph node metastasis. It is important to observe the postoperative courses carefully during 6 months from surgical resection in order to detect the early recurrences promptly.
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P3.16 - Surgery (ID 732)
- Event: WCLC 2017
- Type: Poster Session with Presenters Present
- Track: Surgery
- Presentations: 1
- Moderators:
- Coordinates: 10/18/2017, 09:30 - 16:00, Exhibit Hall (Hall B + C)
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P3.16-029 - Recurrence within a Year after Complete Resection of Primary Lung Cancer (ID 9227)
09:30 - 16:00 | Author(s): Fumi Ohsawa
- Abstract
Background:
Optimal postoperative follow-up method for lung cancer patients is not determined. Investigation of early recurrence risk may help differentiating the patients who should be intensively follow up, and further lead to improve prognosis of those cases. We clinicopathologically evaluated the lung cancer patients with recurrence within a year after complete resection.
Method:
We retrospectively reviewed 63 patients with recurrent diseases after complete resection of lung cancer between 2006 and 2016 in our institution.
Result:
We found 32 patients (50.1%) who had recurrent disease within a year after resection (former group), 31 patients (49.2%) over a year after resection (latter group). Average ages of each group were 70.1 years for the former, and 68.4 years for the latter. As for histological types, the former were composed of Adenocarcinoma (Ad) 12 / non-Ad 20, and the latter composed of Ad 27/ non-Ad 4 cases. Ad was found more frequently in the latter than the former, significantly（p<0.0001）. Pathological stage (I/ II-IV) of each groups were 8 / 24 cases for the former, 18 / 13 cases for the latter. The former had more advanced stages than the latter, not significantly. Average tumor size (mm) was 45.5 for the former, 32.3 for the latter, not significantly. Pleural invasion (-/+) were 11/32 cases for the former, 11/31 for the latter, not significantly. On the other hand, Lymphatic invasion (-/+) were 24/32 cases for the former, 16/31 for the latter（p=0.0168）. Vessel invasion (-/+) were 23/32 for the former, 14/31 for the latter（p=0.0313）. The former had more Lymphatic invasion (+), Vessel invasion (+) patients than the latter, significantly. Postoperative survival times were 503.6 days for the former in average, 1704.1 days for the latter. The prognosis of the latter was better than the former（p＜0.05）. The number of deaths were 19 for the former (including 1 case with intercurrent disease death), 9 for the latter (same 2 cases). The former had more cases of death （p=0.0238）than the latter, significantly.
Conclusion:
Lung cancer patients with recurrence within a year after resection showed non-Ad histology and lymphovasclar invasion positivity more frequently, than those over a year after resection. Such patients had shorter survival time and more number of deaths than those over a year, showing poorer prognosis.
