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Sung Kyoung Kim



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    P1.03 - Chemotherapy/Targeted Therapy (ID 689)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Chemotherapy/Targeted Therapy
    • Presentations: 1
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      P1.03-030 - Prognostic Impact of the Presence of COPD in Patients with NSCLC under Conventional Systemic Chemotherapy (ID 8793)

      09:30 - 16:00  |  Author(s): Sung Kyoung Kim

      • Abstract

      Background:
      Effects of the presence of COPD on clinical outcomes in patient with advanced stage NSCLC cancer were inconclusive. Aim of our study is to evaluate the effects of COPD on overall survival of NSCLC patients who undergo conventional chemotherapy as 1st line treatment.

      Method:
      Advanced NSCLC (stage IIIB and IV) received first-line chemotherapy from January of 2008 to December 2015 were enrolled from 6 university hospitals. Patients who underwent pretreatment pulmonary function test were selected in the analyses, and COPD was defined according to GOLD guideline: FEV1/ FVC < 0.7. Primary endpoint was the overall survival according to the patients’ clinicopathological characteristics.

      Result:
      A total of 197 patients comprised of 92 patients (46.7%) in the COPD group and 105 (53.3%) in the non-COPD group were enrolled in the analysis. The median duration of follow-up for survived patients was 23.9 months. The presence of COPD was a significant risk factor for mortality in the univariate analysis (HR, 1.402; p = 0.037), however not in the multivariate analysis (HR, 1.275; p = 0.144). The patients with COPD have poor clinical outcomes in subgroups of smokers and stage IV cancer, significantly.

      Conclusion:
      : COPD does not have clinical impact of overall survival of advanced NSCLC patients who undergo conventional chemotherapy. However COPD was a poor prognostic factor in terms of overall survival of in smokes and stage IV NSCLC patients. Further studies which evaluate clinical effects of airflow obstruction management on lung cancer patients can elucidate the clinical impact of COPD.

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    P1.12 - Pulmonology/Endoscopy (ID 698)

    • Event: WCLC 2017
    • Type: Poster Session with Presenters Present
    • Track: Pulmonology/Endoscopy
    • Presentations: 1
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      P1.12-001 - Flexible Bronchoscopic Cryotherapy in Patients with Malignant Central Airway Obstruction (ID 8428)

      09:30 - 16:00  |  Presenting Author(s): Sung Kyoung Kim

      • Abstract

      Background:
      Although malignant central airway obstruction has poor prognosis, cryotherapy can be used as a palliative treatment. The objective of this study is to evaluate the role of flexible bronchoscopic cryotherapy in patients with malignant central airway obstruction.

      Method:
      Clinical data of patients who performed flexible bronchoscopic cryotherapy for recanalization of malignant central airway obstruction from March 2014 to September 2016 were analyzed retrospectively.

      Result:
      29 patients (21 males) were enrolled. Median age was of 65 years (range, 54-82) and median ECOG performance status was 3 (range, 1-3). Causes of malignant central airway obstruction were primary lung cancer of 21 cases (Squamous cell carcinoma, 12 cases; small cell carcinoma, 9 cases) and endobronchial metastasis of 8 cases (soft tissue sarcoma, 2 cases; renal cell cancer, 4 cases; glottis cancer, 1 case; endometrial cancer, 1 case). Obstruction sites were as follows: carina and both main bronchus, 4 cases; left main bronchus, 9 cases; right main bronchus, 8 cases; bronchus intermedius, 8 cases. Degree of obstruction was classified into three categories: complete, 6 cases; partial non-passable with scope, 5 cases; partial passable with scope, 18 cases. Type of obstruction was classified into two types: intrinsic obstruction, 8 cases (all endobronchial metastasis); extrinsic obstruction, 21 cases (all primary lung cancer). Complete recanalization was achieved in 8 cases (27.6%), and all of them were endobronchial metastasis. Partial recanalization was achieved 21 cases (72.4%). Dyspnea was improved in 23 patients (79.3%). There was no immediate complication, such as respiratory failure or massive bleeding. Figure 1



      Conclusion:
      Cryotherapy with flexible bronchoscopy is a feasible and effective treatment for malignant central airway obstruction, especially due to endobronchial metastasis. For more clarification, further prospective study of large scale will be required.