Author of

• 16831

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  P1.06 - Poster Session with Presenters Present (ID 458)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Advanced NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16851

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    P1.06-020 - Prevalence of Autoimmune Disease in US Veterans With Non-Small Cell Lung Cancer (NSCLC) (ID 4745)

    14:30 - 15:45  |  Author(s): M. Parisi
    • Abstract

    Background:
    Immunotherapy has emerged as an effective treatment strategy in cancer; patients with preexisting autoimmune diseases are often restricted from use. The prevalence of autoimmune disease was 12.5% worldwide (Lerner, Int J of Celiac Disease, 2015) and 24.6% in US patients with lung cancer (LC) (Khan, JAMA Oncol 2016). We report autoimmune disease prevalence in veterans with NSCLC in a real-world setting.
    
    Methods:
    Patients with a unique diagnosis of NSCLC between 1/1/2010 and 12/31/2015 were included. Diagnoses were confirmed by VA Central Cancer Registry and Veterans Health Administration National Patient Care Database. Patients were excluded if they had <1 VA visit within 1 year prior to diagnosis. Baseline autoimmune diseases were identified using ICD-9 codes for 36 organ-specific and 7 systemic autoimmune diseases. Autoimmune disease was defined as having ≥1 claim of any type (broad definition) or having ≥1 inpatient claim or ≥2 outpatient claims ≥30 days apart (narrow definition).
    
    Results:
    40,371 patients with NSCLC were included (stage IV adenocarcinoma n=6525, stage IV squamous cell carcinoma (SCC) n=3421). Almost all patients were male (99.9%). Autoimmune disease prevalence was greater per broad vs narrow definition in all patients (15.7% vs 13.6%), adenocarcinoma patients (13.4% vs 11.0%), and SCC patients (15.0% vs 12.3%). By broad definition, 13.4% of all patients, 11.7% of patients with stage IV adenocarcinoma, and 13.0% of patients with stage IV SCC had 1 autoimmune disease; 2.3%, 1.7% and 2.0% had >1 autoimmune disease, respectively. The most common autoimmune diseases in all 3 patient populations were psoriasis, chronic rheumatic heart disease (CRHD), rheumatoid arthritis (RA), Addison disease, and ulcerative colitis (Table).Figure 1
    
    
    
    Conclusion:
    Prevalence of autoimmune disease was lower in the predominantly male US veterans with NSCLC than the general population with LC; the prevalence was similar regardless of stage or histology. The most frequent autoimmune diseases were psoriasis, CRHD, and RA.