Author of

• 16751

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  P1.05 - Poster Session with Presenters Present (ID 457)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Early Stage NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16788

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    P1.05-037 - Histopathologic Results of Surgically Resected Pure Ground-Glass Opacity Lung Nodules (ID 6269)

    14:30 - 15:45  |  Author(s): Y.W. Do
    • Abstract

    Background:
    Little is known about the histopathology of persistent pure ground-glass opacity lung nodules (GGNs).
    
    Methods:
    We reviewed preoperative chest computed tomography (CT) in patients who underwent surgery for GGNs between Mar. 2015 and May 2016. A total of 58 surgically resected pure GGNs persistent more than 3 months and their diameter at CT scan less than 15 mm in 41 patients were included. Then pathologic reports of 58 GGNs were retrospectively reviewed.
    
    Results:
    Median age of the patients was 58 years (range, 33 – 75) and 34 patients (83.3%) were female. Median preoperative follow-up duration of GGNs was 11 months (range, 3–114). In spite of all patients were asymptomatic, the reasons of check-up the chest CT included to follow-up for other malignant disease in 29 patients (70.1%), routine health check-up in 10 (25.0%), and to follow-up of other benign disease in 2 (4.9%). Among a total 45 operations, preoperative CT-guided localization was performed in 31 operations (68.9%). Extents of resection included wedge resection in 29 patients (64.4%), segmentectomy in 7 (15.6%), and lobectomy in 9 (20.0%). Lymph node sampling or dissection was performed in 27 operations (60.0%). Among 58 resected GGNs, median diameter of GGNs was 8mm (range, 3-15mm), median number of resected GGN per operation was 2 (range, 1-5). The distribution of pathologic diagnosis included benign disease in 3 GGNs (5.2%), atypical adenomatous hyperplasia (AAH) in 4 (6.9%), adenocarcinoma in situ (AIS) in 17 (29.3%), minimally invasive adenocarcinoma (MIA) in 19 (32.8%), and invasive adenocarcinoma (IA) in 15 (25.9%). The diameter of GGNs classified into 3 categories (0 – 5mm, 6 – 10mm, 11 – 15mm) were associated with pathologic invasiveness (Cochran-Amitage test, p = 0.005). However, follow-up duration of GGNs classified into 3 categories (3 - 12 months, 13 - 24 months, more than 25 months) was not associated with diameter of GGNs (p = 0.453) or pathologic invasiveness (p = 0.893). Among 18 GGNs tested, epidermal growth factor receptor (EGFR) mutations were detected in 5 GGNs (27.7%).
    
    Conclusion:
    The prevalence of lung adenocarcinoma (AIS, MIA, IA) was 87.9% in surgically resected pure GGNs persistent more than 3 months and their diameter at CT scan less than 15 mm. A diameter of GGNs diameter was associated with pathologic invasiveness. Further studies are needed for persistent pure GGNs not affected by partial-volume effect of CT in non-selected patients.