Author of

• 16751

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  P1.05 - Poster Session with Presenters Present (ID 457)

  • Event: WCLC 2016
  • Type: Poster Presenters Present
  • Track: Early Stage NSCLC
  • Presentations: 1
  • Moderators:
  • Coordinates: 12/05/2016, 14:30 - 15:45, Hall B (Poster Area)

  • 16775

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    P1.05-024 - Preoperative Neuron-Specific Enolase to Albumin Ratio is a Prognostic Biomarker for Patients with Operable Non-Small-Cell Lung Cancer (ID 5273)

    14:30 - 15:45  |  Author(s): Y. Zhang
    • Abstract
    • Slides

    Background:
    Neuron-specific Enolase (NSE) is a widely used tumor biomarker in small-cell lung cancer (SCLC) diagnosis, and serum albumin (Alb) levels are commonly used as indicators of the nutritional status of cancer patients. However, the prognostic value of these markers in combination has not been examined. This study was designed to explore the value of the combination between NSE and Alb in non-small-cell lung cancer (NSCLC).
    
    Methods:
    We retrospectively evaluated the prognostic value of the preoperative NSE to albumin ratio (NAR) in 319 patients with operable NSCLC. We analyzed associations among the NAR, clinicopathological characteristics, and inflammatory biomarkers. Univariate and multivariate analyses were performed to identify the clinicopathological characteristics associated with OS. Furthermore, we compared the prognostic value of the NAR with other established prognostic indexes by evaluating the area under the curves (AUC).
    
    Results:
    The optimal NAR cutoff level was found to be 3.2×10[-7]. We found that a higher NAR was associated with more advanced TNM staged cancers (P=0.041) and higher tumor stage (P=0.011).The NAR was also associated with the inflammatory biomarker albumin/globulin ratio (AGR, P=0.032), but not the neutrophil/lymphocyte ratio (NLR, P=0.295) or platelet/lymphocyte ratio (PLR, P=0.260). In multivariate analyses, the NAR was an independent prognostic factor for NSCLC patients (P<0.001). The AUC of the NAR was higher than the NLR, PLR or AGR at 24 and 36 months of follow-up.
    
    Conclusion:
    The preoperative NAR might be an independent prognostic factor for patients with operable NSCLC, and a higher NAR indicates a poorer prognosis.
    
    

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