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E. Millastre



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    P1.05 - Poster Session with Presenters Present (ID 457)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Early Stage NSCLC
    • Presentations: 1
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      P1.05-005 - Programmed Death-Ligand 1 (PD-L1) in Resected Lung Adenocarcinomas (LA) in a University Hospital (ID 6101)

      14:30 - 15:45  |  Author(s): E. Millastre

      • Abstract

      Background:
      The role of monoclonal antibodies inhibiting of the Programmed Death-1 and its ligand (PD-1/ PD-L1) pathway have been described in advanced disease. The knowledge of the role of this pathway in early stages of lung cancer is still limited. We assessed the incidence of PD-L1 expression in tumour cells of samples of resected lung adenocarcinomas and its prognostic role.

      Methods:
      A retrospective analysis of patients (p) with lung adenocarcinomas radically resected at our Institution between 2004 and 2011 has been conducted. PD-L1 was determined by Immunohistochemistry (SP263, Ventana® assay). A cut-off value of 5% of positive tumour cell was chosen.

      Results:
      112 tumours from 107 p were included. Median age was 62 years. 81% were male, 88% had exposure smoking, baseline performance status was 0 – I – II (62,5% - 26,8% - 10,7%) and pathological stage was I – II – III – IV (49,1% - 26,8% - 23,2% - 0,9%). Fourteen p (12%) expressed PD-L1>5%. They were mostly male (71%), smokers (93%), baseline performance status was 0 – 1 – 2 (64% - 29% - 7%), the most common histological subtype was poorly differentiated adenocarcinoma (64%) and pathological stage was I – II – III (28% - 21% - 50%). One p (7,7%) harboured EGFR mutation, none (0%) were ALK positive and 6 p (46,2%) had a K-RAS mutation. With a follow-up of 52 months median disease free survival (DFS) was 49 months and overall survival (OS) 58 months. Median DFS was shorter in p with expression of PD-L1 (27 months) that in negative tumours (49 months) (p=0,45). Median OS showed a similar pattern (32 vs 66 months respectively) also favouring PD-L1 negative p (p=0,05).

      Conclusion:
      In our series, patients with resected adenocarcinomas expressing PD-L1 in >5% of cells showed a worse disease free and overall survival than patients without such expression.

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    P1.06 - Poster Session with Presenters Present (ID 458)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Advanced NSCLC
    • Presentations: 1
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      P1.06-028 - Description of the Patients with Advanced Squamous NSCLC Treated in a Single Institution (ID 6171)

      14:30 - 15:45  |  Author(s): E. Millastre

      • Abstract

      Background:
      Squamous carcinomas are a distinct subtype of NSCLC. Even if it is no longer the most frequent one, still remains a significant percentage of NSCLC patients in our practice. Besides, clinical presentation, associated comorbidities and available therapies are different for non-squamous subtypes. Assessing their characteristics may help to optimize therapy.

      Methods:
      DAta from patients with a diagnosis of advanced (stage IV patients plus patients with lower stages but not amenable for any local therapy) squamous NSCLand treated in our Hospital between 2009-15 were reviewed.

      Results:
      209 patients (p) were found. Median age was 69 years (40-89). Gender: Male in 89.5%. PS: ECOG 0= 9.1%, 1= 45.9%, 2= 38.3%, 3= 6.7%. By stage, I= 0.5%, II 3.4%, III 27.7%, IV 68.7%. Therapy: 29.1% of p did not receive any systemic therapy and 70.9% receive chemotherapy (CT). CT included a platinum in 69p (carboplatin 47p, cisplatin 22p) and 61p received a non-platinum scheme (gemcitabine-vinorelbine 21p, monotherapy 40 p (gemcitabine 8p, oral vinorelbine 23p, other 9p). Patients with better PS (p<0.001) and stage less than IV (0.02) were more probable to receive CT and also that CT given included platinum. Overall survival (OS) was 6.5 months (5.4-7.6) for the whole group. For stage IV patients, it was significantly shorter: 5.4 months (p=0.03). OS for patients not receiving therapy was 2.7m (vs 7.7m in those treated). Within stage IV OS was shorter for female vs male (4.2 vs 5.8m), and decreased with poorer performance status: 0, 13.5, 1, 8.2m, 2, 3.8m, 3, 2.2m.

      Conclusion:
      Squamous carcinomas are still the second most frequent subgroup of NSCLC. They are more frequently male and almost half of them presented with PS ≥2. Of them, 29% did not even receive CT and out of those treated, only 60% were considered fit to receive a platinum-based therapy. OS was generally poor, but it was remarkably low in patients with PS 2 or worse. Median OS in untreated patients was under 3 months.