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S. Oh

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    P1.03 - Poster Session with Presenters Present (ID 455)

    • Event: WCLC 2016
    • Type: Poster Presenters Present
    • Track: Radiology/Staging/Screening
    • Presentations: 1
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      P1.03-023 - Ground-Glass Opacity (GGO) with Semi-Consolidation: Clinicopathological and Radiological Correlations Compared to Pure-GGOs of the Lung (ID 5656)

      14:30 - 15:45  |  Author(s): S. Oh

      • Abstract

      There has been a great advancement in understanding natural history of ground-glass opacity (GGO), which represents histological lepidic growth in early stage pulmonary adenocarcinoma. Among them, some GGO lesions reveal increased density of GGOs without obvious consolidation on thin-section computed tomography (TSCT), i.e., GGO with semi-consolidation. However, little is known regarding clinicopathological and radiological relationship of this new entity.

      During 2004 and 2016, we underwent AAA (2327) surgical resections for clinical-stage IA lung cadenocarcinoma. Among them, 286 (12.3%) GGO lesions without any consolidations were identified based on the findings on TSCT. They were categorized into two groups; pure-GGO (PG) and GGO with semi-consolidation (SC) according to the radiological findings. Semi-consolidation is defined as GGO with increased homogenous density without consolidation on TSCT. Clinicopathological factors were analyzed between these two groups. Survivals were calculated by Kaplan-Meier estimation methods.

      Of the cases, 172 (60.1%) showed PG and 114 (39.8%) showed SC. Significant or marginal differences were clinically observed between PG and SG groups regarding age (59.4y vs. 63.0y, p=0.02), pack-year smoking status (10.2 vs. 11.6, p=0.084), tumor size (12.2cm vs. 13.9cm, p=0.06), respectively. Noninvasive lesions including atypical adenomatous hyperplasia, adenocarcinoma in situ or minimally invasive adenocarcinoma were observed in 144 patients (83.7%) of PG and 74 (64.9%) of SC, however, the frequency of invasive adenocarcinoma or lymph-vascular invasions were significantly higher in SC group compared to PG group (15.7% vs 33.9%, p=0.001: 4.3% vs 0.5%, p=0.040) despite their GGO appearances. There was no lymph node metastasis in both PG and SC groups. Overall lung-cancer specific survival is 100% to date in both PG/SC groups with mean follow-up period of 97months.

      Despite the conventionally same category as a native GGO appearance on TSCT, invasive adenocarcinoma was frequently observed in radiologically dense GGO lesions, indicating that PG might progress to SC over time. Surgical outcome for both groups are excellent. Therefore, more studies regarding optimal surgical procedures and long-term outcome of these two groups should be warranted.