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M. Kaji
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P1.06 - Poster Session/ Screening and Early Detection (ID 218)
- Event: WCLC 2015
- Type: Poster
- Track: Screening and Early Detection
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.06-025 - Statistical Analysis of 18F-FDG-PET/CT Findings of Ground Glass Nodule (GGN) (ID 1689)
09:30 - 17:00 | Author(s): M. Kaji
- Abstract
Background:
18F-FDG-PET/CT (PET/CT) is one of the most important image inspections for the diagnosis of lung cancer. However, there are often false negatives caused by small lesions such as Ground Glass Nodule (GGN). Whether PET/CT is useful for the diagnosis of GGN is unknown. Therefore, we analyzed the relationship of computed tomography (CT) findings (size, properties) and maximum standardized up-take values (SUV-max) of GGN.
Methods:
We had 69 patients with pathological-Stage IA-IB lung adenocarcinoma who underwent surgical resection and PET/CT from January 2010 to December 2014. We retrospectively examined their clinical characteristics, CT findings, and PET/CT findings.
Results:
Characteristics of 69 patients were as follows, 47 - 86 years old (median 70 years old), female/male: 39/30, pathological-Stage IA/IB: 59/10. GGN diameter: 1.1 - 41.13mm (median 19.43mm), Solid-part diameter: 0.0 - 23.23mm (median 4.55mm), Solid-part-ratio (solid-part diameter / GGN diameter): 0 - 77% (median 20%). SUV-max was insignificant to 6.8 (median 1.0). Correlation coefficient of each factor and SUV-max were as follows, GGN diameter: 0.49, Solid-part diameter: 0.54, Solid-part-ratio: 0.41 (Pearson’s product-moment correlation). All pure-GGN show no significant SUV-max (<2.5), even though there are some large GGN included (max 40.0mm). GGN diameter >20mm or solid-part diameter >5mm were significant factor of FDG-uptake (Fisher’s exact test). In this study, SUV-max was lower than significant level with solid-part diameter <4.55mm.
Conclusion:
There was no significant SUV-max with diagnostic value in pure-GGN. PET/CT is not useful for pure-GGN or small part-solid nodule (solid-part diameter <4.55mm). There is higher correlation in the solid-part diameter and SUV-max. We should keep in mind the limitation of PET/CT for GGN diagnosis.
