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S. Sakiyama
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P1.06 - Poster Session/ Screening and Early Detection (ID 218)
- Event: WCLC 2015
- Type: Poster
- Track: Screening and Early Detection
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.06-005 - The Correlation between Visceral Pleural Invasion in T1a Non-Small Lung Cancer and Lymph Node Metastasis (ID 2638)
09:30 - 17:00 | Author(s): S. Sakiyama
- Abstract
Background:
Visceral pleural invasion (VPI) of non-small cell lung cancer (NSCLC) has been recognized as a poor prognostic factor. Peripheral lung cancers often invade visceral pleura, and positive VPI upstages the T category of tumors from T1a to T2a. In addition, it is possible that peripheral lung cancers with positive VPI causes lymph nodes metastasis because of subpleural lymphovascular invasion. In this study, we statistically analyzed the correlation between VPI and lymph node metastasis.
Methods:
129 patients with NSCLC and a tumor diameter of ≤ 2cm underwent lobectomy or segmentectomy with systematic lymph node dissection in Tokushima University Hospital between January 2008 to December 2013. Excluding 11 patients who were not examined by FDG-PET before the surgery, we reviewed the medical records of 118 patients to obtain information on age, sex, CEA, SUVmax, CT findings, pathological VPI and lymph node metastasis.
Results:
Patient characteristics were as follows: median age of 66.5 (range: 41-86); male/female: 52/66; histologic type adenocarcinoma/squamous cell carcinoma/other: 103/12/3. 13(36.1%) of 36 patients who were suspected to be with visceral pleural invasion by preoperative CT findings were diagnosed with pathological visceral pleural invasion. The mean SUVmax on FDG-PET in patients with VPI was significantly higher than that of patients without VPI(p=0.01). Pathological visceral pleural invasion was identified in 19(16.1%) of 118 patients and associated with high incidence of lymph node metastasis significantly on multivariable analyses (p=0.00).
Conclusion:
VPI is important factors of lymph node involvement in small peripheral lung cancers. It is difficult to identify VPI of peripheral lung cancers by preoperative CT findings. FDG-PET may be useful for diagnose VPI.
