Author of

• 13580

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  P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)

  • Event: WCLC 2015
  • Type: Poster
  • Track: Biology, Pathology, and Molecular Testing
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)

  • 13617

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    P1.04-037 - Lung and Hypopharyngeal Angiosarcoma (AS) in a Renal Transplant Patient: Case Report (ID 1636)

    09:30 - 17:00  |  Author(s): W. Martinez
    • Abstract
    • Slides

    Background:
    (AS) are rare malignant soft tissue tumors of endothelial cell origin representing 2% of all sarcomas. Most AS develops in the absence of precursor lesions. To date, only 20 cases of (AS) have been described after renal transplantation, occurring mostly on the skin or in a dialysis fistula, their pulmonary location is very rare. We report the case of a patient with a renal transplant who presents a hypo pharyngeal and a right lower lobe (RLL) lesion where a Angiosarcoma was documented.
    
    Methods:
    Clinical History Revision
    
    Results:
    A 78 years-old patient, ex-smoker, with end-stage renal failure received a cadaveric donor renal transplant in 2000. Immunosuppressed with relatively low doses of tacrolimus and steroids, graft function remained stable with a serum creatinine in 1,2 until January 2015 when he consults with dysphonia, dysphagia, cough, and mild hemoptysis. The patient had bilateral neck lymphadenopathy, bilateral basal crackles and the rest of the physical examination within normal parameters. Pulmonology evaluated the patient finding a hypopharyngeal mass and another with round morphology in RLL that were metabolically active in PET-CT. A hypopharyngeal biopsy is taken and a CT-guided transthoracic puncture, finding a high grade undifferentiated tumor of mesenchymal origin, expressing Vimenin and CD10, with vascular marker CD31 and gene C-Myc. Gene p53 and Ki-67 in 90% of the tumor. No lymphoid or epithelial line markers are expressed. The patient is currently in chemotherapy and immunotherapy.
    
    Conclusion:
    The use of potent immunosuppressive agents has significantly reduced the rates of acute rejection after renal transplantation. However, in­creased cancer incidence after renal transplan­tation has become an important problem. Skin tumors, post-transplant lymphoproliferative dis­eases and organ cancers are the most common malignant tumors seen in these patients. Angiosarcoma is rarely seen in this group of patients, and location in lung and hypopharynx without evidence elsewhere of commitment affectation is very rare. Figure 1 Figure 2
    
    
    
    
    
    

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