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H.J. Isaksson
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P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.04-023 - Primary Adenocarcinoma in the Lung Reclassified - Histological Subtypes and Outcome (ID 2131)
09:30 - 17:00 | Author(s): H.J. Isaksson
- Abstract
Background:
Non-small cell lung cancer (NSCLC) comprises 85% of primary lung cancer, where adenocarcinoma, squamous cell and large cell carcinoma are the most common histological types. Recently a new classification of primary adenocarcinomas of the lung was published. The aim of this study was to review the histology of all primary lung adenocarcinomas operated on in Iceland during a 20 year period, 1991-2010, using the new criteria and assess the impact of histology on survival.
Methods:
This nationwide study included 301 patients with primary lung adenocarcinoma (mean age 65.5 yrs., 56% female) that underwent resection in Iceland between 1991-2010. Tumors were reclassified according to the current IASLC/ATS/ERS pulmonary adenocarcinoma classification system. Overall survival was estimated by the Kaplan-Meier method and multivariate Cox regression analysis used to evaluate prognostic factors of survival, including histological subtype
Results:
Acinar predominant adenocarcinoma was the most common histological subtype (45%). Solid predominant with mucin production comprised 24% of the cases, lepidic predominant 19% and papillary predominant 8%. There was one in situ adenocarcinoma, three minimally invasive adenocarcinomas and seven invasive mucinous adenocarcinomas. Overall survival at 1 year for all histological subtypes of adenocarcinoma was 81.1% and 42.6% at 5 years. A statistically significant difference in survival between the histological subtypes was not seen (log-rank test, p=0.43). Using multivariate analysis advanced stage and age predicted a worse outcome. Histologic subtyping did neither predict survival in uni- or multivariate analysis.
Conclusion:
Acinar and solid predominant adenocarcinoma are the most common histological subtypes for primary lung adenocarcinoma in Iceland. There was not a statistical difference in survival according to histological subtypes and the subtyping was not a prognostic factor of survival.
