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T. Shiomi
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P1.04 - Poster Session/ Biology, Pathology, and Molecular Testing (ID 233)
- Event: WCLC 2015
- Type: Poster
- Track: Biology, Pathology, and Molecular Testing
- Presentations: 1
- Moderators:
- Coordinates: 9/07/2015, 09:30 - 17:00, Exhibit Hall (Hall B+C)
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P1.04-022 - Prognostic Significance of Solid or Micropapillary Component in Pulmonary Invasive Adenocarcinoma Measuring ≦ 3cm (ID 623)
09:30 - 17:00 | Author(s): T. Shiomi
- Abstract
Background:
According to the International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification, both solid- and micropapillary-predominant pulmonary adenocarcinoma have been reported to have a poor prognosis. Although pulmonary adenocarcinoma with some solid or micropapillary component have also been reported to have a poor prognosis, the ratio of these component to be chosen as the cutoff value for a prognostic factor remains controversial.
Methods:
A total of 115 patients with pulmonary invasive adenocarcinoma measuring ≦ 3 cm who underwent curative surgery at Tottori University Hospital between January 2005 and December 2008 were included. Patients with variants of invasive adenocarcinoma were excluded from this study. The median follow-up time was 78.0 months. A total of 84, 9, and 22 patients underwent lobectomy, segmentectomy, and wedge resection, respectively, and 100, 5, and 10 patients had stages I, II, and III, respectively. The tumors were divided into subtypes according to the IASLC/ATS/ERS classification. Cases with solid component occupying ≧ 5% of the entire tumor were defined as S-positive (S+), and cases with micropapillary component occupying ≧ 1% of the entire tumor were defined as MP-positive (MP+). Of the 115 adenocarcinoma, 30 and 85 were S+ and S-, and 27 and 88 were MP+ and MP-. The clinical characteristics and pathologic data of all 115 adenocarcinoma were retrospectively evaluated. The Kaplan-Meier method was used to estimate the recurrence-free survival (RFS) and overall survival (OS) rates, and the log-rank test was used to compare the RFS and OS among the subgroups.
Results:
The 5-year OS rate of cases that were S＋ and S- was 92.5% and 62.1%, respectively (log rank P < 0.001). The 5-year RFS rate of cases that were MP＋ and MP- was 77.3% and 51.9%, respectively (log rank P = 0.001). On multivariate survival analysis, the presence of solid component proved to be an independent prognostic factor, and the presence of micropapillary component proved to be an independent recurrence factor.
Conclusion:
The presence of solid component occupying ≧ 5% of the entire tumor was an independent predictor of a poor prognosis in pulmonary invasive adenocarcinoma measuring ≦ 3cm. The presence of any micropapillary component, even if only in 1% of the entire tumor, was a risk factor for post-operative recurrence and it affected the prognostic value.
