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J. Hung



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    P1.03 - Poster Session/ Treatment of Locoregional Disease – NSCLC (ID 212)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Locoregional Disease – NSCLC
    • Presentations: 1
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      P1.03-027 - Factors Predicting Lymph Node Metastasis in Resected Lung Adenocarcinoma of 2cm or Smaller (ID 840)

      09:30 - 17:00  |  Author(s): J. Hung

      • Abstract
      • Slides

      Background:
      The predictive value of the new International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society (IASLC/ATS/ERS) classification of lung adenocarcinoma predicting lymph node metastasis in lung adenocarcinoma has not been well demonstrated. The aim of the study is to demonstrate factors associated with lymph node metastasis in patients with resected lung adenocarcinoma of 2 cm or smaller.

      Methods:
      The clinicopathological characteristics of 246 patients with completely resected lung adenocarcinoma of 2cm or smaller at Taipei Veterans General Hospital between 2004 and 2012 were retrospectively reviewed. The association between clinicopathological variables and lymph node metastasis was analyzed by univariate and multivariate logistic regression.

      Results:
      Among the 246 patients, there were 215 (87.4%) patients with N0 status, 13 (5.3%) with N1 status, and 18 (7.3%) with N2 status. Greater tumor size (P < 0.001) and predominant pattern group (micropapillary/solid predominant) (P = 0.001) were significantly associated with higher percentage of N1 or N2 lymph node metastasis. In multivariate analysis, greater tumor size (P < 0.001), and micropapillary/solid predominant pattern (P = 0.029) were significant predictors of N1 or N2 lymph node metastasis in tumors of 2cm or smaller. Micropapillary/solid predominant pattern (P = 0.031) was also a significant predictor of N2 lymph node metastasis in multivariate analysis.

      Conclusion:
      Tumor size and histological subtypes were significantly associated with lymph node metastasis in lung adenocarcinoma of 2cm or smaller. Micropapillary/solid predominant pattern is a significant predictor of lymph node metastasis.

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