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H. Niwa

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    P1.02 - Poster Session/ Treatment of Localized Disease – NSCLC (ID 209)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Localized Disease - NSCLC
    • Presentations: 1
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      P1.02-014 - Predictive Factors of Postoperative Acute Exacerbation of Interstitial Pneumonia for Patients with Lung Cancer (ID 3048)

      09:30 - 17:00  |  Author(s): H. Niwa

      • Abstract
      • Slides

      Currently, postoperative acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) accounts for the most common cause of death after pulmonary resection for lung cancer. Preoperative risk assessment and prevention of postoperative AE is essential for the operative performance improvement.

      From 2000 through 2013, a total of 1730 patients underwent pulmonary resections for primary lung cancer. One hundred and two patients (5.9%) were diagnosed the lung cancer combined with IIP based on the postoperative pathological findings. Postoperative AE was defined as acute exacerbation within 30 days after the operation.

      Postoperative AE was observed in 9 patients (8.8%), of which 6 patients (66.7%) died of respiratory failure. Although three patients had improved and discharged, two patients of which finally died with re-exacerbation. All of the postoperative AE patients were men having all cases smoking history, and many of them were advanced stage. The AE patients were significantly worse than non-AE patients in following clinicopathological factors. Preoperative serum LDH(248±52IU/l vs 206±45)、CRP(1.6±1.8mg/dl vs 0.9±1.8)、PaO2(78.1±7.8mmHg vs 84.9±10.5) and %VC(78.9±14.3% vs 94.4±15.1). Moreover, for the postoperative AE patients, the changes of these factors and X-ray or CT findings before operation were analyzed. An exacerbation before operation observed for serum LDH in five patients, CRP in three patients, and increased lung opacity on imaging findings observed in four patients.

      To see the exacerbation of laboratory values (LDH, CRP) and imaging findings (increasing lung opacity) during preoperative time, there is a possibility of selecting high-risk patients of postoperative AE.

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