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H. Kreis



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    P1.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 206)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Advanced Diseases - NSCLC
    • Presentations: 1
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      P1.01-039 - Lung Cancer in Kidney Transplant Recipients: A Case-Control Retrospective Study of 30 Patients (ID 595)

      09:30 - 17:00  |  Author(s): H. Kreis

      • Abstract
      • Slides

      Background:
      Kidney transplantation has dramatically increased during last decades. As significant progress has been made in the prevention and treatment of infections, cancer has become a major cause of concern. Limited data exist about lung cancer after kidney transplantation.

      Methods:
      The data from 2003 to 2012 of all transplanted patients with lung cancer in three French kidney transplant centers were retrospectively reviewed. 30 cases were included. Lung cancer incidence was determined in two centers for the 2008-2012 period. Each case was matched with two controls. Controls were patients without solid organ transplantation matched with the cases for age (<30; 30-50; 50-65; >65 years), gender and diagnosis date of lung cancer.

      Results:
      Lung cancer incidence in renal transplanted patients was 1.89/1000 person-years for the 2008-2012 period. Our cohort was mainly formed of male smokers around 60 years old, all current or former smokers. 43% were diagnosed by routine exams. Histopathological distribution was different with more squamous cell carcinoma. As expected, hypertension and ischemic heart disease were more prevalent but the other comorbidities and characteristics were the same in both groups. 60% had a stage IV cancer. Surgery was performed as often as in controls if the stage allowed it and advanced stage received full dose chemotherapy. Palliative care only was given to 20% of the patients. Hospitalization for infectious complications was somewhat higher in the cases group but global survival was similar.

      Conclusion:
      Kidney transplant recipients are likely to develop lung cancer. Despite frequent radiologic examinations, the majority of patients had advanced stage disease at diagnosis. Therapeutic management and prognosis did not differ between patients and control. As current or past smoking habit was present in all cases, a screening strategy should focus on smokers in this high-risk population. Our study was not designed to determine if other risks factors could be identified.

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