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A.A. Nagy

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    P1.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 206)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Advanced Diseases - NSCLC
    • Presentations: 1
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      P1.01-035 - Clinico-Epidemiological Features and Survival Outcome in Patients with NSCLC: Ain Shams Clinical Oncology Department 5-Year Data (ID 460)

      09:30 - 17:00  |  Author(s): A.A. Nagy

      • Abstract
      • Slides

      Primary lung cancer is the most common malignant neoplasm worldwide. In spite of the fact that in Egypt, according to various institutional and hospital-based data, bronchogenic carcinoma is the fifth most common malignancy among males the seventh most common cancer in females, its incidence continues to increase with no improvement in treatment outcome. This study aims to analyze the epidemiological factors and clinicopathological features of NSCLC in egyptian patients and evaluate the various lines of treatment and their impact on survival.

      This study included the examination and analysis of data collected retrospectively from the medical records of 504 patients diagnosed with NSCLC who were treated at Department of Clinical Oncology and Nuclear Medicine, Ain Shams University, Cairo-Egypt in the period from January 2008 till December 2012.

      The median age of the cohort was 59 years (Range 33-80)with male predominance (74.4%) and 59.1% were of urban residence. The most common symptom at presentation was dyspnea (49.2%). Most patients were stage IV at presentation (73.2%) and adenocarcinoma was the most common histology (52.6%). About 85% of the patients received active treatment. The Median PFS after first,second and third lines was 3, 4 and 2 months respectively and the median OS was 8 months. Factors which were associated with a statistically significant difference in median OS were age <60 years versus ≥ 60 years (10 and 7 months respectively, p<0.001), female versus male gender (10 and 8 months respectively, p<0.001), urban versus rural residence (9 and 8 months respectively , p=0.03), smokers versus non-smokers (8 and 10 months respectively, p<0.001), patients presenting with non-neurological symptoms and those presenting with neurological symptoms (9 and 6 months respectively, p< 0.001) and the receiving treatment versus no treatment (10 and 5 months respectively, , p<0.001). Cox regression analysis showed that the factors that were associated with shorter OS were age≥ 60 years, not receiving any line of treatment, patients presenting with neurological symptoms and male gender.

      This study shows that the active treatment of patients with NSCLC continues to have an important impact on survival. The fact that rural residence could be associated with worse OS warrants further investigation. We recommend large multicentric prospective studies comparing multimodality treatment approaches and including quality of life assessment.

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