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Z. Zhang

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    P1.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 206)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Advanced Diseases - NSCLC
    • Presentations: 1
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      P1.01-033 - Multiple Organ Metastasis Could Be Identified as Poor Prognostic Factors for NSCLC (ID 145)

      09:30 - 17:00  |  Author(s): Z. Zhang

      • Abstract
      • Slides

      Metastatic spread of cancer to distant organs is the reason for most cancer deaths.Lung cancer frequently metastasize to bone, brain, lung, andliver, causing a shorter survival. Therefore, increased knowledgeof metastatic patterns is crucial in the treatment of patients. In this article, we evaluate the prognostic significance of postoperative metastasis organ in NSCLC.

      The relationship between postoperative metastasis and survival was investigated. Patients who underwent curative lobectomy and pathologically diagnosed with NSCLC between 2005.1 and 2011.12 were included in our study. SPSS 20.0 software was used for analysis. Survival rates were calculated using Kaplan-Meier survival plots and analyzed using the Cox regression. The variables with statistical significance in univariate analysis were included in multivariate analysis. Significant difference between groups could be found if p value was less than 0.05.

      Finally 94 patients including 53 male and 41 female were enrolled in our study. The average age was 62 years old. Metastasis occurred during early stage (less than 2 years postoperatively) in 45 patients, and during late stage (more than 2 years postoperatively) in 49 patients. Single organ metastasis and multiple organ metastasis were found in 85 and 9 patients separately. the most popular metastatic site was pulmonary, and then bone and brain. The overall survival (OS) of all included patients was 41.5%. The median survival time was 43 months and 29 months for single metastasis and multiple metastasis groups separately. There was significant difference in the OS between GS and GM group (45.9% Vs 0, P<0.001). The median survival time was 50 months and 32 months for early metastatic patients and late metastatic patients separately. Significant difference could be in the OS between GS and GM group (53.3% Vs 30.6%, COX P=0.130, Breslow P=0.014). Cox regression showed age TNM stage (P=0.003), and single organ metastasis (P<0.001) were significant prognostic factors for NSCLC.

      Lung, bone, and brain were the most popular metastatic organ for postoperative NSCLC. The presence of multiple organ metastases could be identified as an independent poor prognostic factor in NSCLC.

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