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L. Chen

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    P1.01 - Poster Session/ Treatment of Advanced Diseases – NSCLC (ID 206)

    • Event: WCLC 2015
    • Type: Poster
    • Track: Treatment of Advanced Diseases - NSCLC
    • Presentations: 1
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      P1.01-012 - Kinase Domain Mutation Positive Lung Cancers Are Sensitive to Intrapleural Perfusion with Hyperthermic Chemotherapy (IPHC) Complete Treatment (ID 1248)

      09:30 - 17:00  |  Author(s): L. Chen

      • Abstract

      Lung cancer is the global leading cause of cancer-related deaths. A significant portion of lung cancer patients harbor kinase domain mutations in the epidermal growth factor receptor (EGFR). While EGFR tyrosine kinase inhibitors (TKI) effectively shrink tumors harboring mutant EGFR, clinical efficacy is limited by the development of TKI resistance. As such, effective alternatives are desperately needed.

      We have been treating M1a lung cancer patients through intrapleural perfusion with hyperthermic chemotherapy (IPHC) followed by cycles of systemic chemotherapy (we termed this procedure IPHC complete treatment, IPHC-CT). Tumor shrinkage was analyzed in mutant EGFR-positive patients after IPHC-CT treatment. Furthermore, patient-derived cell lines driven by mutant EGFR were treated with hyperthermic chemotherapy to study the mechanisms of effect of IPHC-CT on cancer cells.

      Tumor shrinkage was detected in patients whose tumor harbored EGFR kinase domain mutation. Hyperthermia and cisplatin synergistically downregulated EGFR protein levels in tumor cells, which ultimately elicited apoptosis.

      IPHC-CT is effective in treating EGFR kinase domain mutation positive lung cancer patients.