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S. Schild



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    O10 - Stereotactic Ablative Body Radiotherapy (ID 104)

    • Event: WCLC 2013
    • Type: Oral Abstract Session
    • Track: Radiation Oncology + Radiotherapy
    • Presentations: 1
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      O10.02 - Radiation Therapy Oncology Group (RTOG) protocol 0915: A randomized phase II study comparing 2 Stereotactic Body Radiation Therapy (SBRT) schedules for medically inoperable patients (pts) with stage I peripheral Non-Small Cell Lung Cancer. (ID 68)

      16:15 - 17:45  |  Author(s): S. Schild

      • Abstract
      • Presentation
      • Slides

      Background
      To select the most favorable treatment regimen based on the rate of grade 3 or higher protocol-specified adverse events (psAEs) at 1 year.

      Methods
      Pts with documented baseline medical conditions precluding lobectomy and biopsy-proven peripheral (greater than 2 cm from the central bronchial tree) T1/T2, N0 (clinically node negative by PET), M0 tumors were eligible. Patients (pts) were randomized to receive either 34 Gy in one fraction (arm 1) or 48 Gy in 4 consecutive once-daily fractions (arm 2). Rigorous central accreditation and quality assurance assessments were used to assure pts were treated according to protocol guidelines. The study was designed to detect whether psAEs rate>17% at a 10% significance level (1-sided) and 90% power. Secondary endpoints included primary tumor control (PC) rate, 1-year overall survival (OS), progression-free survival (PFS). The regimen selection criteria were based on pre-specified rules of psAEs and PC for each arm. Formal comparisons were not performed.

      Results
      The study opened in September 2009 and closed in March 2011 after accruing a total of 94 pts. Median follow up was 20.6 months. Of 86 evaluable pts, 41 were in arm 1 and 45 in arm 2. Baseline pt and tumor characteristics were balanced between both arms. 4 (9.8%) pts on arm 1 (95% CI: 2.7-23.1%; p=0.151) and 6 (13.3%) pts on arm 2 (95% CI: 5.1-26.8%; p=0.337) experienced psAEs. 39 (95.1%) pts on arm 1 and 45 (100%) pts on arm 2 received planned SBRT treatment. Contouring compliance indicated 100% and 95.6% of targets and 89.5% and 82.2% of normal tissue structures were outlined per protocol/minor deviations, for arms 1 and 2, respectively. OS at 1 year was 85.4% (95% CI: 70.3-93.1%) for arm 1 pts and 91.1% (95% CI: 78.0-96.6%) for arm 2. PFS at 1 year was 78.0% (95% CI: 62.1-87.9%) for arm 1 and 84.4% (95% CI: 70.1-92.3%) for arm 2. The PC rates at 1 year were 97.1% (95% CI: 85.1-99.9%) for arm 1 and 97.6% (95% CI: 87.1-99.9%) for arm 2.

      Conclusion
      At one year, 34 Gy in one fraction met pre-specified criteria with respect to adverse events and primary control, and therefore is selected as the experimental arm for a planned phase III trial. Supported by RTOG U10 CA21661 and CCOP U10 CA37422 grants from NCI.

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    P3.08 - Poster Session 3 - Radiotherapy (ID 199)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Radiation Oncology + Radiotherapy
    • Presentations: 1
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      P3.08-018 - Stereotactic body radiotherapy for oligometastatic disease to the lung (ID 2371)

      09:30 - 16:30  |  Author(s): S. Schild

      • Abstract

      Background
      With the increasing penetration of stereotactic body radiotherapy (SBRT) into cancer practice, there is growing interest in applying this technique to patients with limited metastatic disease. We reviewed our single institution experience using SBRT in the treatment of oligometastatic pulmonary disease.

      Methods
      A retrospective review was performed to identify patients treated at our institution with SBRT for pulmonary metastases between 3/2008 and 1/2013. Treatment decisions were multidisciplinary and a biopsy was performed when feasible. The gross tumor volume (GTV) was non-uniformly expanded to create an internal target volume (ITV) to encompass tumor motion based on 4-dimensional computed tomography (CT). A 5 mm uniform expansion of the ITV was then applied to create the planning target volume (PTV). The most common dose/fractionation schedule was 48-50 Gy in 4-5 fractions. Cone beam CT was used for daily image guidance. Overall survival (OS), time to distant failure (TTDF), and local control (LC) were estimated from the end of the first SBRT procedure using the Kaplan-Meier method. Toxicity was scored based on CTCAEv4. Median follow up was 15 months (range 3-60).

      Results
      64 patients underwent 66 SBRT procedures to treat 74 lesions. There were 36 males (56%) and 28 females (44%) with a median age of 71 years (range 42-90). The most common primary disease sites were lung (n=23; 36%), colorectal (n=10; 16%), melanoma (n=9; 14%), and head and neck (n=5; 8%). The target lesion represented the only site of metastatic disease in 32 patients (50%); 20 patients (31%) had additional pulmonary metastases but no extra-thoracic disease; 12 patients (19%) had both pulmonary and non-pulmonary sites of metastases. Median lesion size was 2.3 cm (range 0.6-6.8). Median, 1-year, and 2-year OS was 21 months, 73%, and 49%, respectively. Distant metastatic disease progression was observed in 37 patients (58%) at a median time interval of 12 months. Patients (n=52) with no extra-thoracic disease at the time of SBRT had a significantly longer TTDF compared to patients (n=12) with concurrent extra-thoracic disease (median 13 vs. 5 months; 1-year failure rate 47 vs. 73%; p = 0.02) without a difference in OS (median OS not reached vs. 20 months; 1-year OS 75 vs. 63%; p=0.1). Local failure was observed for 4 lesions resulting in an 18-month LC rate of 88%. There were 11 toxicities observed in 10 patients including fatigue (n =1, grade 1), dyspnea (n=1, grade 1), dermatitis (n=1, grade 2), rib fracture (n=1, grade 2), and pneumonitis (n= 5, grade 2; n=2, grade 3).

      Conclusion
      SBRT is a reasonable treatment for patients with pulmonary metastases. High rates of local control can be achieved with acceptable toxicity. Only 2 patients (3%) developed grade 3 pneumonitis (oxygen indicated). In this high risk population, new distant metastatic progression was common, especially among patients who present for SBRT with known extra-thoracic sites of disease at the time of SBRT. However, among patients with solitary lung lesions or oligometastatic disease limited to the chest, survival was encouraging. We will continue to utilize SBRT in this population of oligometastatic disease with careful patient selection.

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    PL03 - Presidential Symposium Including Top Rated Abstracts (ID 85)

    • Event: WCLC 2013
    • Type: Plenary Session
    • Track:
    • Presentations: 1
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      PL03.05 - An intergroup randomized phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) chemoradiotherapy (CRT) +/- cetuximab (cetux) for stage III non-small cell lung cancer (NSCLC): Results on cetux from RTOG 0617 (ID 1424)

      08:15 - 09:45  |  Author(s): S. Schild

      • Abstract
      • Slides

      Background
      The two primary objectives of RTOG 0617 were to compare the overall survival(OS) differences of 1) standard-dose(SD)(60Gy) versus high-dose(HD)(74Gy) radiotherapy (RT) with concurrent chemotherapy(CT); and 2) the addition of cetux to standard CRT. Cetux is a monoclonal Ab targeting EGFR with activity when combined with CT in metastatic NSCLC and head and neck cancer (HNC), and with RT in locally advanced HNC.

      Methods
      This Phase III Intergroup trial randomized pts in a 2 x 2 factorial design. Concurrent CRT included weekly paclitaxel(45 mg/m2) & carboplatin(AUC=2). Pts randomized to cetux received a 400 mg/m2 loading dose on Day 1 followed by weekly doses of 250 mg/m2. All pts were to receive 2 cycles of consolidation CT. This is the initial report of survival outcome based on cetux. The trial was designed for 450 evaluable patients with 80% power and a 1-sided alpha of 0.0125 to detect a 29% reduction in OS failure for each comparison (RT and cetux).

      Results
      544 pts were accrued, and 419 and 465 are eligible for RT and cetux analyses. Median follow up is 18.7 months. Cetux delivery was acceptable in both the concurrent and consolidation phases. Therapy related ≥Grade 3 non-hematologic toxicity was higher in the cetux group; 70.5% vs 50.7% (p<.0001). Grade 4 and 5 events were 35.8% and 28.2%, respectively. Median survival was 23.1 vs 23.5 months, & 18-month OS rates were 60.8% vs 60.2% on the cetux vs non-cetux arms, respectively (p=0.484, HR=0.99), which crossed a protocol-specified futility boundary for early reporting. As previously reported, median survival times and 18-month OS rates for SD and HD arms were 28.7 vs 19.5 months, and 66.9% vs 53.9% respectively (p=0.0007, HR=1.56). There was no significant interaction between RT dose and the use of cetux. The OS rates for the 4 arms of this trial are shown in Table. An H-score analysis, a measure EFGR positivity, is forthcoming.

      Table: Overall Survival Rates with 95% CI (pts accrued while all 4 arms were open)
      Time 60 Gy 74 Gy 60 Gy + Cetux 74 Gy + Cetux
      12m 78.4% (68.9, 85.4) 62.6% (51.7, 71.6) 80.0% (70.8, 86.6) 74.7% (64.9, 82.2)
      18m 67.9% (57.6, 76.2) 52.3% (41.5, 62.0) 67.1% (56.8, 75.5) 58.0% (47.6, 67.1)

      Conclusion
      In pts receiving CRT for Stage III NSCLC, 74 Gy is not superior to and may be worse than 60 Gy in terms of OS. Cetux provides no survival benefit in the setting of CRT for Stage III NSCLC.

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