Author of

• 11389

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  O10 - Stereotactic Ablative Body Radiotherapy (ID 104)

  • Event: WCLC 2013
  • Type: Oral Abstract Session
  • Track: Radiation Oncology + Radiotherapy
  • Presentations: 1
  • Moderators:H. Onishi, J.Y. Chang
  • Coordinates: 10/28/2013, 16:15 - 17:45, Parkside 110 A+B, Level 1

  • 11390

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    O10.01 - Exploring the optimal biologically effective dose of stereotactic body radiation therapy for Stage I non-small-cell lung cancer - An update (ID 3030)

    16:15 - 17:45  |  Author(s): J. Wang
    • Abstract
    • Presentation
    • Slides

    Background
    To investigate the relationship between the different levels of biologically effective dose (BED) and the outcome of stereotactic body radiation therapy (SBRT) for Stage I non–small-cell lung cancer (NSCLC).

    Methods
    Eligible studies were identified on Medline, Embase and the Cochrane Library from January 2001 to March 2013. According to the quartile of included studies, BED was divided into four dose groups: low (＜100Gy), medium (100–112.3Gy), medium to high (112.3–135Gy), high (>135Gy). To obtain pooled estimates of overall survival (OS), local control rate (LCR), cancer-specific survival(CSS), regional failure rate(RFR), distant failure rate (DFR)，data were combined in a random effect model. The difference in pooled estimate among BED groups was assessed with the Pearson chi-squared test. The meta-regression model was used to explore the relationship between the characteristics of the studies and the prognostic index.

    Results
    Fifty-nine observational studies with a total of 5,562 patients were included in the meta-analysis. Pooled estimates of 2-year and 3-year OS in the medium BED (79%, 71%) group were higher than in the low (64%, 57%) or medium to high BED (69%, 57%) or high groups (66%, 56%), respectively (p＜0.001, p＜0.001, p＜0.001,respectively). Pooled estimates of 2-year LCR in the medium BED (89%) group was lower than in medium to high BED (94%)or high groups (94%), respectively (p=0.003,0.009 respectively). While no significant differences were observed between each two of four different levels of BED and the 3-year RFR.

    Conclusion
    Based on the meta-analysis, a statistically significant OS benefit at 2 and 3 years can be demonstrated in the treatment of Stage I NSCLC with the delivery of medium BED compared with low, medium to high BED or high BED. The medium BED (range, 100–112.3Gy) for SBRT may currently be more beneficial and reasonable in Stage I NSCLC.

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