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Y. Bai



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    O18 - Cancer Control and Epidemiology II (ID 133)

    • Event: WCLC 2013
    • Type: Oral Abstract Session
    • Track: Prevention & Epidemiology
    • Presentations: 1
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      O18.07 - A Retrospective Cohort Mortality Study in Jingchuan of china - the Largest Nickel Population in World (ID 94)

      10:30 - 12:00  |  Author(s): Y. Bai

      • Abstract

      Background
      Nickel is an essential trace metal used in the occupational setting and is naturally found in the general environment, resulting in both occupational and nonoccupational exposures to individuals at varying levels. Exposure to nickel has been associated with several toxicites and the International Agency for Research on Cancer has concluded that there is sufficient evidence in humans associating exposure to nickel or nickel compounds with risk of lung cancer. We evaluated overall and cause-specific mortality among Chinese workers involved in nickel production or utilization in order to examine the long-term health effects of occupational exposure to nickel compounds.

      Methods
      The study design was a retrospective cohort mortality study including 432,526 workers who were involved with nickel mining or smelt between 2001 and 2010. We calculated standardized mortality ratios (SMR) using the death rates of Gansu Province in China, and estimated by the exact probabilities of the Poisson distribution.

      Results
      Overall, the all-cause mortality was decreased in all workers compared to the general population of Gansu province (SMR= 0.53, 95%CI: 0.51-0.55). Analyses examining cause-specific mortality revealed an increase in the mortality from bronchogenic carcinoma and lung cancer (SMR = 2.05, 95% CI = 1.84-2.29), cor pulmonale (SMR =4.08, 95% CI = 3.25-5.01), and silicosis (SMR = 13.59, 95%CI =11.90-15.52) in the workers exposed to nickel.

      Conclusion
      This study confirmed a significant excess of mortality from diseases of the lung including silicosis , lung cancer, and cor pulmonale among workers involved in nickel mining or smelt in China.

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    P1.22 - Poster Session 1 - Epidemiology, Etiology (ID 166)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Prevention & Epidemiology
    • Presentations: 1
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      P1.22-001 - An Nickel Workers Cohort Study in China (Jinchuan Cohort)-the Largest Nickel Population in World (ID 95)

      09:30 - 16:30  |  Author(s): Y. Bai

      • Abstract

      Background
      Nickel is one of the most widely distributed and used metals in the world. Exposure to nickel compounds can result in a variety of adverse effects on human health. The China Nickel Workers Cohort Study (Jinchuan cohort) is estimated to include more than 50 000 nickel workers.

      Methods
      Since 2011, all staff and workers have been eligible for a medical examination every 2 years, and these workers who participated in the medical examination will be in-person interviewed with a standardized and structured questionnaire with trained interviewers and will be included in the Jinchuan cohort study. The medical examination includes a comprehensive physical examination, biochemical examination, epidemiologic survey and collection of biological samples. The Jinchuan cohort has the largest data set from a cohort of nickel exposed workers with both questionnaire and laboratory-based information and the exposure and disease information will be updated every 2 years through the biannual survey and medical examination.

      Results
      The comprehensive epidemiological and biological data will permit the evaluation of a number of hypotheses concerning the health effects of nickel exposure. The unique repository of blood samples including blood cell, plasma, and serum collected at the time the epidemiology survey will provide a population-based platform to examine biological indicators that closely correlate with nickel exposure and illness by using molecular epidemiologic methods. All of the cryopreserved blood samples are being stored in cryogenic tubes for future studies.

      Conclusion
      We are conducting the first occupational epidemiological study of nickel exposure in China among over 50 000 workers Comprehensive physical and biochemical examinations, an epidemiologic survey, and collection of biologic samples from workers are being used to evaluate the relationship between nickel exposure, cancer, and other health outcomes The cohort will be followed every two years with a repeat medical examination to update exposure and outcome information