Author of

• 10643

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  P1.07 - Poster Session 1 - Surgery (ID 184)

  • Event: WCLC 2013
  • Type: Poster Session
  • Track: Surgery
  • Presentations: 1
  • Moderators:
  • Coordinates: 10/28/2013, 09:30 - 16:30, Exhibit Hall, Ground Level

  • 10683

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    P1.07-040 - Outcomes of Surgical Treatment for Isolated Adrenal Metastasis in Non-Small Cell Lung Cancer: A Systematic Review and Pooled Analysis (ID 2943)

    09:30 - 16:30  |  Author(s): X. Gao
    • Abstract

    Background
    Several small studies have reported that some non-small cell lung cancer (NSCLC) patients with isolated adrenal metastasis can achieve long-term survival through an adrenalectomy followed by a surgical resection for primary lung cancer. However, most studies treated such patients as IV stage and suggested that the survival outcome was poor. The choice of treatment approach for such patients is still controversial.

    Methods
    A search for publications on surgical treatment for primary lung cancer and isolated adrenal metastasis from NSCLC was performed via the MEDLINE and Siencedirect datebase. Studies reporting on survival outcomes were included. When we analyze data to determine which clinical characteristics predict long-term survival, studies not allowing separation of outcomes between groups were excluded. Synchronous metastasis was defined as an adrenal metastasis which occurred before or within 6 months after the primary lung cancer.

    Results
    There were 11 publications contributing 87 patients (age from 35 to 78 years, 82.1% men and 17.9% women). Median overall survival was 16 months. The 1-year survival, 2-year survival and 5-year survival was 64.0%, 37.7% and 29.2% respectively. Median overall survival (OS) for patients with synchronous metastasis was shorter than those with metachronous metastasis (12 months vs 31 months, P = .017). However, the difference of media overall survival between patients whose pathology of primary lung cancer was adenocarcinoma and squamous carcinoma was not significant (20 months vs 13 months, p = .068). Whether there was mediastinal lymph node metastasis or not was not a prognostic factor because there was no striking difference in media overall survival (p = .496). The patients with ipsilateral adrenal metastasis had the same median overall survival as those with contralateral tumors.

    Conclusion
    For an isolated adrenal metastasis from NSCLC, part of the patients undergoing surgical treatment for both primary lung cancer and isolated adrenal metastasis have a long survival. Patients with metachronous metastasis predict a better survival.