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A. Krams

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    P1.07 - Poster Session 1 - Surgery (ID 184)

    • Event: WCLC 2013
    • Type: Poster Session
    • Track: Surgery
    • Presentations: 1
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      P1.07-022 - Results of study evaluating inflammatory biochemical parameters and oxidative stress in patients undergoing VATS and open lobectomy for early stage NSCLC. (ID 1871)

      09:30 - 16:30  |  Author(s): A. Krams

      • Abstract

      Surgery results in a wide range of unfavorable alterations in body homeostasis which are referred to as surgical stress. Low total antioxidant capacity could be indicative of oxidative damage associated with increased morbidity and mortality. When surgical stress generates oxygen radicals, they are quickly detoxified by antioxidant network, leading to a decrease in the potential of antioxidants which can be measured. Video-assisted thoracoscopic (VATS) and open lobectomy approaches were evaluated to determine if there is any difference in acute phase response and oxidative stress associated with surgery for early stage non-small cell lung cancer (NSCLC).

      Our prospective study included 30 patients who underwent lobectomy for early stage NSCLC: by conventional open thoracotomy approach (n=15) and VATS approach (n=15). We measured changes in plasma total antioxidant capacity (TAC), lactate dehydrogenase (LDH) and C-reactive protein (CRP), fibrinogen, total protein (TP) concentrations and WBC count preoperatively, 24h and 72h postoperatively, on the day of drain removal, and 1 and 9 days after the drain removal. Concentrations of TAC, LDH and TP in pleural fluid were observed 24h, 72h postoperatively and on the day of drain removal.

      Changes in TAC, LDH, CRP, fibrinogen, TP and WBC count in plasma for both groups followed similar kinetics. The response of CRP and LDH (p<0.05), as well as WBC count and fibrinogen (0.05

      Our results suggest that the VATS approach compared to open thoracotomy approach could be associated with less tissue trauma and surgical stress. We can expect that decreasing intraoperative oxidative stress could dynamically contribute to the improvement of postoperative recovery.